SCIENCE: Huntington's disease changes the way human neurodevelopment is developed.
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Last Update: 2020-07-28
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Source: Internet
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Author: User
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Although Huntington's disease is a neurodegenerative disease that only appears at an advanced stage, mouse studies and neuroimaging studies of carriers of asymptomatic mutations have shown that Huntington's disease may affect neurodevelopmentTo determine whether it was true that the researchers examined the tissues of human fetuses (pregnancy weeks) that carry huntington's disease mutationsThese tissues exhibited significant abnormalities in the developing cortex, including abnormal occurrence of dislocation neurogenic polarity and differentiation of dislocation neurogenic nucleogenias and differentiated nucleosomes of the mutated huntingtin protein and abnormal changes in cell cycle progressionThe researchers observed the same phenomenon in the embryos of Huntington's disease mice, and they linked these anomalies to defects in the migration of protocellular nucleogenesSo Huntington's disease has a neurodevelopmental abnormality, not just a degenerative disease
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