Science: Heavyweight! The key mechanism behind the mystery of aging.

In a new study published in Beijing, the University of California, San Diego, a team of scientists has uncovered the key mechanism behind the mystery of aging: they isolate two different pathways in the aging process and devise a new method -- genetic programming to extend cell lifeHuman life expectancy is determined by the aging of individual cellsResearchers studied wine yeast to find out whether different cells ageated at the same speed and for the same reasonThis is an operational model of the aging mechanism that also applies to the aging pathways of skin and stem cellsWe know that many of the damage factors include chromatin instability, mitochondrial dysfunction, and reactive oxygen, all of which contribute to cell agingIn each single cell, how these factors combine to drive the aging process is still a mysteryScientists have found that cells with the same genetic material and in the same environment age in very different waysTheir fates unfold through different molecular and cellular trajectoriesUsing a combination of microflow control technology and time-lapse microscopes combined with computer modeling and other techniques, the team found that genetic wild-type cells exhibited two phenotype changes during agingThey are named "Mode" and "Mode" aging, respectivelyAbnormal changes in the structure of nucleosomes and mitochondria are markers of aging in many organisms, indicating age-related organ dysfunctionThe components of the kernel include, and the rnayscoproteinNuclear kernels are the assembly sites for gene storage, synthesis processing, and ribosome subunitsThe conservative lysine deacetylase () specifically encoded by the longevity gene maintains stability through mediated silenceThe silent researchers used a green fluorescent protein to report the gene inserted into the transcription intervalSilence inhibits the expression of the reported gene by increasing the fluorescence indicating that silence disappearsCells exhibit sporadic loss of silence in the early stages of aging By late-aging the mode cells experienced a sustained loss of silence but the pattern cells did not consistent with the nuclear renition decline of the model cells Niacinamide ( ) is an inhibitor exposed to most cells that induces its aging, which suggests that and silence plays a role in driving mode aging Photo Source: All patterns of aging cells of nucleokernels grow and break up but pattern cells do not However, mitochondria in the pattern cells maintained a normal tubular pattern throughout life and the pattern of mitochondria clustered before the cell died, consistent with the mitochondria decline previously observed in a small number of cells So these two aging patterns are associated with different organmalfunctions: the pattern kernel decline mode mitochondrial decline Photo Source: Cells set foot on two different paths of nucleosomes or mitochondria early in life and follow this "aging pathway" through aging and death throughout their life cycle At the heart of the control, researchers have discovered a main circuit that guides these aging processes They developed a new model of the aging landscape and found that they could manipulate and ultimately optimize the aging process Computer simulations helped researchers create a new aging pathway characterized by significant lying longer-lived by modifying the main molecular circuit Photo Source: "Our study raises the possibility of rationally designing genes or chemotherapy to reprogram how human cells age, " said the study's author and associate professor of molecular biology at the University of California, San Diego Our goal is to effectively delay human aging and extend human life "Researchers will now test their new models in more complex cells and organisms and eventually look for similar ways of aging in human cells They also plan to test chemical techniques and evaluate how the combination of treatment and the drug "cocktail" can guide the longevity path Study co-author and professor of molecular biology at the university said: "Much of the work on this study has benefited from the formation of a strong interdisciplinary team The most important thing for this team is that we not only have to model but also experiment to determine if the model is correct These iterative processes are critical to our work "