Science has revealed that New York is quietly testing the treatment of the heartburn drug famorteddine for COVID-19!

MAY 15, 2020 /PRNEWSWIRE
BIOON/- A GROWING NUMBER OF TREATMENTS FOR THIS NEW CORONAVIRUS, INCLUDING AN UNLIKELY CANDIDATE DRUG: FAMOTITIN, AN ACTIVE COMPOUND USED TO TREAT HEARTBURN
OVER-THE-COUNTER
PEPCIDDOn April 7, the first group of COVID-19 patients at Northwell Health Center in New York City began receiving fentifyl intravenous lying at nine times the dose of heartburnUnlike the drugs being tested at 23 other hospitals, such as Sarilumab and Gilead's Redsieway, Northwell's study of Famotitinin is confidential so that it can be kept safe before other hospitals, and even the federal government, start buying them"If we talk to the wrong person or talk about it too early, the drug supply chain will break down," said Kevin Tracey, a former neurosurgeon who is in charge of hospital systems research"
as of Saturday, 187 patients in critical coVID-19, including many who use ventilators, had been included in the trial, which had a total target of 1,174Reports and molecular simulations from China suggest that the drug appears to be binding to a key enzyme of severe acute respiratory syndrome (SARS-CoV-2) to workBut the hype surrounding hydroxychloroquine and chloroquine -- unproven antimalarial drugs touted by President Donald Trump and some doctors and scientists -- has made Tracey cautious so as not to stir up premature enthusiasmHe was tight-lipped about the future of Famotitin, at least until the interim results of the first 391 patients were released"If it does work, we'll know in a few weeks," he saidimage source: https://cn.bing.com
In the United States, a global infectious disease doctor named Michael Callahan was the first to call attention to the drugCallahan works at Massachusetts General Hospital and has a wide range of contacts in the field of biological defenseHe has worked in disease hotspots around the world, including another coronavirus outbreak in 2003, SARSIn mid-January, he worked on aavian influenza project in Nanjing, China With the outbreak of the COVID-19 epidemic in Wuhan, he followed his Chinese colleagues to the city the virus kills one in five people over the age of 80 of all ages had poorer prognosis for people with hypertension and chronic obstructive pulmonary disease Callahan and his Chinese colleagues wonder why many survivors are not rich "Why didn't these people die because of COVID-19?" "。 looking at the records of 6,212 COVID-19 patients, doctors noted that many of the survivors suffered from chronic heartburn, using famobutine instead of the more expensive omeprazole, a drug of choice among wealthy Americans and China The mortality rate for patients admitted to COVID-19 with famotitin was about 14%, while for patients who did not use paritytin, the mortality rate was 27%, although the analysis was crude and the results were not statistically significant but that's enough to keep Callahan on the issue He then briefed Robert Kadlec, assistant secretary for preparedness and response to the U.S Department of Health and Human Services, and then reported to Robert Malone, chief medical officer of Alchem Laboratories, a Contract Manufacturing Agency in Florida Malone is part of a confidential project called DOMANE that uses computer simulations, artificial intelligence and other methods to quickly identify drugs and other safe compounds approved by the U.S Food and Drug Administration (
FDA ) that can be used to counter threats such as new viruses Malone is concerned about a viral enzyme called papaya protease, which helps pathogens replicate To see if the fentanyl binds to the protein, he usually needs the 3D structure of the enzyme, but it will take several months So Malone hired computational chemist Joshua Pottel, president of Montreal Molecular Prediction, to predict it from two crystal structures of the 2003 SARS coronavirus protease, combined with the RNA sequence of the new coronavirus it's hardly plug-and-play In addition, they compared the genetic sequences of old and new proteases to eliminate key structural differences Pottel then tested how 2,600 different compounds interacted with the new protease The model produced dozens of promising results, with pharmaceutical chemists and other experts shrinking to three Famotitinis is one (However, the compound has not yet been present in in vitro screening in existing antiviral drug libraries.) with attractive Chinese data and models pointing to Famotitin, a low-cost, universally safe drug, Callahan contacted Tracey for a double-blind random study Decline in renal function in patients with COVID-19 will be excluded because high doses of famotitin can cause heart problems is getting After the FDA approval, Northwell started the work with its own funds Because injectable famotitinis is not widely used, it can take weeks to get half of the required famotitin in a sterile bottle On April 14, Kadlec's U.S Advanced Biomedical Research and Development Agency (BARDA) offered Alchem a $20.7 million pilot contract, most of which was paid by Northwell the study's draft plan is intended only to assess the efficacy of Themoedine, but Trump's "game-changer" antimalarial drug is fast becoming the standard treatment for hospitalized COVID-19 patients This means that researchers can only recruit enough subjects to conduct trials of a combination of famotitin and hydroxychloroquine image source: https://cn.bing.com
anecdotal evidence encouraged Northwell's researchers After talking to Tracey, David Tuveson, director of the Cold Spring Harbor Laboratory Cancer Center, recommended Famotitin, an engineer at a New York City hospital, to his 44-year-old sister She tested positive for COVID-19 and developed fever Her lips turned dark blue due to lack of oxygen She took the first large dose of famotitin on March 28 The next morning, she had a fever and the oxygen saturation of the blood returned to normal According to a spreadsheet of medical records shared by Tuveson and the journal Science, five of the sick colleagues, including three confirmed to have COVID-19, also showed a significant improvement in their condition after taking an over-the-counter version of the drug Many COVID-19 patients can recover with simple symptom-relieving medications, but Tuveson attributes this to heartburn medications "I would say it's penicillin," he said Timothy Wang, director of gastroenterology at Columbia University Medical Center, , received an e-mail about Tuveson's experience, which spread widely among doctors, and found more clues about the future of Famotitin in his retrospective review of 1,620 hospitalized COVID-19 patients Last week, he shared the findings with Tracey and Callahan and published the paper as co-author The paper is currently being published in Annals of Internal Medicine However, all three researchers stressthat that the real test is the ongoing experiment "We still don't know if it will work "
Kadlec arranged callahan to carry out the medical evacuation of Americans on two severely infected cruise ships Now back in Boston, he said Famotitin's discovery underscores the importance of scientific diplomacy in the face of an unborderline infectious disease Referring to the experience of COVID-19, he said, "In the National Institutes of Health, Harvard or Stanford, no smart person is compared to a general practitioner in Wuhan." (biovalleybioon.com) Reference: New York clinically trially lytestsheartburnburnstostagainscoronavirus