Science: genome map reveals that multiple immune cells are involved in multiple sclerosis

September 27, 2019 / BIOON / -- according to the latest research results published in science, researchers have found a new pathogenesis of multiple sclerosis In a study of 115803 individuals, the authors identified 233 loci in the human genome that are associated with MS The study, the largest in the field of MS to date, is based on DNA samples from 47429 MS patients and 68374 healthy individuals The results confirm the previous conclusions, and provide a wealth of new insights for the molecular mechanism of multiple sclerosis: it seems that the dysfunction of many different types of immune cells in peripheral blood and brain leads to a series of immune reactions, which eventually leads to brain inflammation and neurodegeneration (image source: www Pixabay Com) Philip De, the main researcher of the study "This study shows that the disease is not caused by a single immune cell type, but by a wide range of functional disorders of the immune system," said Dr Jager, director of the multiple sclerosis center and the center for transformation and computational neuroimmunology at Columbia University Irvine Medical Center in New York City Before that, the researchers found that immune cells in bone marrow and blood play an important role in the development of multiple sclerosis In addition, microglia, the immune cells in the human brain, are also considered to be related to the occurrence of diseases However, there is little evidence of a relationship between other brain cells, such as neurons in the brain, and multiple sclerosis Another researcher involved in the study, Dr Nikolaos patsopoulos from Harvard University, said: "our study explains about half of the genetic characteristics of multiple sclerosis By identifying several regions of the genome with multiple genetic variations, this study highlights the complex nature of genetic pairs that lead to multiple sclerosis In addition, we report for the first time the relationship between genetic variation on X chromosome and disease However, there is still a lot of work to be done to fully understand how the human genome participates in Ms " Source of information: genetic map implications broad immune cell involvement in multiple sciences original source: research article multiple sciences generic map implications personal immune cells and microglia in sustainability international multiple sciences genetics consortium Multiple sciences generic map implications personal immune cells and microglia in susceptibility Science, 2019 DOI: 10.1126/science.aav7188