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March 6th, 2021 // - Recently, in a research report published in the international journal Science , scientists from Frankfurt University and other institutions showed through research that there is no signal transduction or command of signal receptor clusters.
Science
In humans, G-protein-coupled receptors (GPCR, G-protein-coupled receptors) represent a large family of receptor molecules with approximately 700 different types.
Image source: M.
In the laboratory, the researchers engineered cells that have about 300,000 Y2 receptors on their surface, and they let these cells grow in a specially developed photosensitive matrix.
Researcher Professor Robert Tampe explained that the accident of this experiment is that the formed receptor cluster can trigger a signal similar to neuropeptide Y, so only through this receptor cluster, we can induce cell movement.
Because the photosensitive lock key is very small compared to the receptor, researchers can use the laser spot to control the assembly/organization of the receptor in the cell membrane with high precision.
Original source:
Original source:M.
M.
Florencia Sánchez, Sylvia Els-Heindl, Annette G.
Beck-Sickinger, et al.
sciencemag.
org/content/early/2021/02/24/science.
abb7657">Photo-induced receptor confinement drives ligand-independent GPCR signaling , Science (2021).
DOI:10.
1126/science.
abb7657 sciencemag.
org/content/early/2021/02/24/science.
abb7657">Photo-induced receptor confinement drives ligand-independent GPCR signaling Science
