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Using BGI Stereo-seq technology, multiple research teams led by BGI have constructed the world's first spatiotemporal cellular map of brain development and regeneration in the salamander (Ambystoma mexicanum), revealing how brain damage heals itself
The research team analyzed the development and regeneration of the salamander brain, identified key neural stem cell subsets in the salamander brain regeneration process, and described the reconstruction of damaged neurons by these stem cell subsets
In contrast to mammals, some vertebrates have the ability to regenerate multiple organs, including parts of the central nervous system
Previous studies have only partially identified which cells and pathways are involved in brain regeneration
By sampling the brains at seven time points (2, 5, 10, 15, 20, 30 and 60 days) after injury to the salamander cerebral cortex region, the researchers were able to analyze cellular regeneration
By comparing molecular changes during brain development and regeneration in salamanders, the researchers found that the formation of neurons during development and regeneration is highly similar
"Using salamanders as model organisms, we have identified key cell types during brain regeneration
In addition to BGI, researchers from China, the United States and Denmark, including Guangdong Provincial People's Hospital, South China Normal University, Wuhan University, School of Life Sciences, University of Chinese Academy of Sciences, Shenzhen Bay Laboratory, Whitehead Institute, University of Copenhagen, etc.
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration
In just half a year, BGI's research results in spatiotemporal omics and single-cell technology have been published in three consecutive academic journals "Cell", "Nature" and "Science" for four consecutive times
About BGI Group
BGI Group is one of the world's leading biotechnology organizations and a pioneer in the field of life sciences, with business covering research, production and application in more than 100 countries and regions
