 Home > Biochemistry News > Biotechnology News > Science Advances Wei Wensheng's research team and collaborators reveal for the first time the three-dimensional structure of chromatin stable chromatin and the mechanism of cell homeostasis by the "useless" sequence of the genome

Science Advances Wei Wensheng's research team and collaborators reveal for the first time the three-dimensional structure of chromatin stable chromatin and the mechanism of cell homeostasis by the "useless" sequence of the genome

 Last Update: 2021-11-13
 Source: Internet
 Author: User

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The non-coding sequences in the human genome play a vital role in a variety of biological processes, such as non-coding RNA, promoters, enhancers, and transposons

On November 3, 2021, University of California San Diego (UCSD) Wang Wei's group and Peking University Wei Wensheng's group jointly published a noncoding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability on Science Advances.

This study is based on 5-kb resolution Hi-C data from 7 human normal cell lines and cancer cell lines (Rao et al .

Figure 1 Discovery of hub sites and high-throughput functional screening

The selected hub sites do not overlap with any protein-coding genes, non-coding RNAs and TADs, and 77.

Figure 2 Excision of the hub site results in simultaneous changes in the three-dimensional structure of chromatin and gene expression

Dr.

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