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On September 2, 2022, Luo Donggen's team from the Beijing University Of Sciences, the McGovern Brain Research Institute, the Center for Quantitative Biology, and the Joint Center for Life Sciences published a research paper entitled "An extra-clock ultradian brain oscillator sustains circadian timekeeping" at Science Advances, reporting a new type of electrical signal and its neural mechanism that maintains circadian
Circadian rhythms are coordinated and controlled by the brain's main biological clock, and its core is the molecular rhythm with a negative feedback cycle of 24 hours between the biological clock genes and their proteins (won the 2017 Nobel Prize in Physiology or Medicine).
For the first time, Luo Donggen's team developed a method that can record the fine electrical activity of all Drosophila clock neurons (3), and in this study, the team further developed the four-electrode patch clamp recording technique for Drosophila brain clock neurons (4), which observed that clock neurons produce synchronized rhythmic action potential releases across the brain, and found that this synchronous release was entirely dependent on synaptic input
Figure 1: XCEOs maintain circadian rhythms
The study identified the first group of oscillator neurons within the drosophila brain and revealed their neural mechanisms in maintaining circadian rhythms (Figure 1
Researcher Donggen Luo is the corresponding author of this article; Dr.
Original link: https://doi.
References:
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