Science Advances: DNA nanotubes break through the blood-brain barrier and bring hope to glioblastoma

Glioblastoma (GBM) is a common type of primary malignant brain tumor

Recently, Johns Hopkins University, University of Minnesota researchers in Science Advances journal published a report entitled: ssDNA Nanotubes for Selective Targeting of glioblastoma and Delivery of doxorubicin for Enhanced Survival of research papers

The research team used DNA nanotechnology to construct a single-stranded DNA nanotubes (ssDNA nanotubes), which can be used as a drug delivery system to cross the blood-brain barrier and target glioblastoma to improve the treatment effect and survival rate

DNA nanotechnology allows researchers to use synthetic DNA for various research purposes.

The research team used a mouse model to test the accuracy of ssDNA nanotubes in targeting glioblastoma by injecting ssDNA nanotubes into both sides of the mouse brain hemisphere: one side is healthy, the other side is full of glial Blastoma

The study specifically observed that tumors were attached to the nanotubes, but they were not present on the healthy side of the brain, indicating that the therapy is unlikely to harm healthy cells

For glioblastoma, it is difficult to completely remove it by surgery, so it is easy to recur

Therefore, the research team used ssDNA nanotubes as a delivery vehicle for the chemotherapy drug doxorubicin

The treatment was stopped two weeks later, and the mice were monitored for about one and a half months

Overall, the results of this study show that ssDNA nanotubes are a promising tool that can break through the blood-brain barrier, target glioblastoma, and can act as a drug delivery system to provide treatment for fatal brain tumors

Original source:

MICHAEL A.