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In our impression, cancer cells are like a vicious thug, but in fact, the life of cancer cells is not easy, and they are always facing the siege from the immune system
However, a new study from the University of Ottawa has discovered a new ability of cancer cells - "hypnotic" NK cells, blood cancer cells will transfer the cell membrane with PD-1 to NK cells, making them "dormant" ” state, thereby inhibiting their anticancer activity
To "hypnotize" NK cells, blood cancer cells transfer their membranes with PD-1 to NK cells, causing them to enter a "dormant" state, thereby inhibiting their anticancer activity
When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer Science Advances
The fight against cancer is a battlefield without gunpowder smoke.
PD-1/PD-L1 immune checkpoint blockade therapy is one of the most effective immunotherapies at present
PD-1/PD-L1
PD-1/PD-L1In this latest study, the research team found that a type of contact between cells, trogocytosis, can explain this doubt
Cytognathism leads to the transfer of PD-1 from tumor cells to NK cells
Cytognathism leads to the transfer of PD-1 from tumor cells to NK cellsIn a mouse model of leukemia, the research team found that cytotoxicity between lymphocytes and tumor cells is very frequent, which also causes NK cells and CD8+ T cells to acquire PD-1 from leukemia cells
Intratumoral lymphocytes acquire PD-1 from tumor cells in a leukocyte mouse model
Intratumoral lymphocytes acquire PD-1 from tumor cells in a leukocyte mouse modelFrom this point of view, the NK cell is not only a ruthless "killer" but also a "thief" - stealing the cell membranes carrying surface protein molecules from other blood cells
In patients with clonal plasma cell disease, the researchers confirmed by immunohistochemistry the cytotoxic effect of NK cells on blood cancer cells—not only PD-1 but also tumor cell markers
PD-1 and CD138 are also present in NK cells from patients with clonal plasmacytosis
PD-1 and CD138 are also present in NK cells from patients with clonal plasmacytosisMichele Ardolino, Ph.
Altogether, this study elucidates a novel mechanism for regulating NK cell function by acquiring PD-1 from tumor cells
This study elucidates a novel mechanism for regulating NK cell function by acquiring PD-1 from tumor cells
Original Source: Original Source:
MOHAMED S.
MOHAMED S.
HASIM, et al.
When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer.
SCIENCE ADVANCES, 13 Apr 2022, Vol 8, Issue 15.
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