Science: A major breakthrough! Scientists have developed an ultra-fast CRISPR-Cas9 gene editing technology that enables precise gene editing in seconds!

JUNE 14, 2020 /PRNewswire/ -- In a recent study published in the international journal Science, scientists from Johns Hopkins University and others developed a new way to accelerate the process of CRISPR-Cas9 gene editing using photosensitive nucleotidesPhoto Source: Ella Marushchenko In the CRISPR-Cas9 gene editing process, the enzyme Cas9 can be used as a scissor to cut the DNA strand at a specific site of gene editing, while guiding RNA molecules will help Cas9 enzymes bind to the DNA site of the intended chain, and part of the process now takes several hours to complete, and in this study, researchers were able to shorten the process to a few secondsIn the article, the researchers alter edicurthed rna sequences by adding photosensitive nucleotide molecules, which block the guided RNA before light is introduced, and once the researchers introduce light, the binding process occurs within seconds, a method that the researchers call "caged" because the guided RNA molecule is limited until it is instructed to complete its work, which the researchers call ultra-fast CrispR gene editingThe researchers note that delaying the editing process is then activated quickly, which may offer the possibility of studying the process in detail, while also increasing the accuracy of gene editing and allowing individual alleles to be edited at once, while also helping researchers develop hybrid mutations and new ways to study complex traitsIn the final study, researcher Medhi said, in the article we describe how to transform the CRISPR-Cas9 tool from a passivation tool to a precise tool, and vfCRISPR technology appears to be a transformative scientific advance because it helps researchers better understand the dynamics of cell responses involved in double-chain fractures during gene editing(BioValleyBioon.com) Original origins: Yang Liu, Roger SZou, Shuaixin He, et alVery fast CRISPR on demand, Science (2020)DOI: 10.1126/science.aay8204