SCI trans Med: study reveals the relationship between gliomas and neurodegenerative diseases

January 26, 2020 / Biovalley / according to a recent study, proteins associated with neurodegenerative diseases such as Alzheimer's may help scientists explore how glioma can become so aggressive This new study on mouse model and human brain tumor tissue was published in the Journal of Science Translational Medicine, and found that tau protein was significantly expressed in glioma cells, especially in patients with better prognosis (image source: www Pixabay Com) in this international cooperative study led by Salud Carlos iii-ufiec Research Institute in Madrid, Spain, the authors found that the prognosis of glioma patients was better when they expressed gene mutations called isocitrate dehydrogenase 1 (IDH1), which stimulated the expression of tau Then, the presence of tau prevents the formation of new blood vessels, which is necessary for the invasive development of tumors Dr Maria g Castro, Professor of neurosurgery and cell and developmental biology at the University of Michigan Medical University, co-author of the paper, said: "we found that the level of microtubule associated protein tau related to neurodegenerative diseases is controlled by epigenetics, and there is a balance between IDH1 / 2 and mutant IDH1 / 2 in normal and glioma tissues In IDH1 / 2 mutant tumors, we found that the expression level of tau decreased with tumor progression " This means that tau levels can be used as biomarkers of tumor progression in mutant IDH1 / 2 glioma, Castro said Source of information: study uncovers unexpected connection between gliomas, neurodegenerative diseases: Ricardo gargini et al The idh-tau-egfr triad definitions the neovascular landscape of diffuse gliomas, Science Translational Medicine (2020) Doi: 10.1126/scitranslmed.aax1501