Sci Trans Med: Probiotic therapy helps treat eczema.

September 11, 2020 /--- A study by the National Institutes of Health found that an experimental treatment that modifies the skin microbiome can safely reduce the severity of eczema and improve the quality of life of children under 3 years of age.
improvements can last up to eight months after treatment stops, researchers report in the September 9 issue of Science Translational Medicine.
, commonly known as eczema, is a chronic inflammatory skin disease characterized by dry, itchy skin and rash.
most commonly found in children and is associated with an increased risk of asthma, haystation and food allergies.
available treatments can help treat eczema symptoms, current options can be expensive and many require multiple uses per day.
(Photo: www.pixabay.com) experimental therapy contains a strain of live roseh rosehrus mucous membranes that are naturally present on the skin, originally isolated from healthy volunteers and grown under tightly controlled laboratory conditions.
for four months, clinical trial participants or their caregivers regularly applied this probiotic therapy to areas of the skin affected by eczema.
children with eczema can be itchy, painful, distracting, and it's very difficult for the whole family," said Anthony S. Fauci, director of the Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health.
early findings suggest that mucosal mucositis therapy may help reduce the burden of eczema symptoms and the need for routine treatment in some children.
numerous genetic and environmental factors can lead to eczema, and scientists are learning more about the role of the skin microbiome in this situation.
2016, NIAID researchers reported that the R. mucosa strain isolated from healthy human skin improved the prognosis of cell culture and eczema mouse models.
based on these preclinical findings, NIAID has initiated a Phase 1/2 clinical trial at the NIH Clinical Center in Bethesda, Maryland, to assess the safety and potential benefits of mucosal mucositis treatment in eczema patients.
results from 10 adults and five children between the ages of 9 and 14 reported in 2018 showed that the treatment was safe and associated with a decrease in eczema severity.
, the trial recruited 15 more children, a total of 20 children aged 3 to 16 with mild to severe eczema.
, lead researcher at NIAID, said: "Most children in this study had significant improvements in skin and overall health after mucosal mucositis treatment.
of therapeutic bacteria remain on the skin and continue to provide benefits after treatment has stopped.
these results support a larger study to further evaluate the safety and effectiveity of this experimental treatment by comparing it with a placebo.
17 out of 20 children in the United States had improved the severity of eczema by more than 50 per cent after treatment.
all treated skin areas, including the inner elbow, inner knee, hand, torso and neck, have improved.
also observed an increase in the function of the skin barrier, which seals moisture and blocks allergens.
addition, most children need fewer corticosteroid hormones to treat eczema, less itching, and a higher quality of life after treatment, and these benefits persist after treatment.
(bioon.com) Source: Probiotic Skin therapy improves eczema in children, study suggests original source: "Therapeutic responses to Roseomosas mucosa in atopic dermatitis may lip involveid-mediated TNF related-epithelial repair" Translational Medical (2020). stm.sciencemag.org/lookup/doi/ ... scitranslmed.aaz8631.