Sci Signal: Drinking alcohol causes small glial cells to activate, disrupts nerve transmission in the brain, and triggers anxiety.

It is well known that drinking alcohol is harmful to health, alcoholism can lead to gastrointestinal, liver, and brain and other organ lesions may even lead to life-threatening conditions.
effects of alcohol on the central nervous system (CNS) often lead to anxiety, cognitive decline, motor dysfunction, and impaired synapses.
alcoholism has had a serious negative impact on the lives of millions of people around the world, and synth transductivity and small glial cell defects are often found in human alcoholics, but the relationship between the two is unclear.
, Sciecne Signaling, a sub-magazine, published a cover paper entitled: Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior.
study found that alcoholism in male mice induced small glial cells to selectively remove excitable synapses between neurons in the pre-cortical cortical layer, thereby suppressing nerve conduction and increasing anxiety behavior.
small glial cells are the main innocular immune cells in the brain, maintaining the dynamic balance of nerve tissue, monitoring the central nervous system, monitoring tissue damage or infection, and checking synapse function.
damaged or infected central nervous system tissue, small glial cells are activated to change morphology, phagocytosis, transcription characteristics, etc. to restore tissue stability.
In many mental illnesses, however, the immune function of small glial cells is impaired, often leading to excessive production of inflammatory media and increased phagocytostic activity, which can adversely affect synapses and negatively affect behavior.
Small glial cells (green) To study the effects of alcohol intake on the responsiveness of small glial cells, the researchers asked mice labeled with small glial cells to drink heavily for ten consecutive days (1.5g/kg, equivalent to five glasses of wine a day in humans).
results show that drinking alcohol produces small glial cell-driven neuroimmune responses in the pre-glial cortical cortical corticals, including altered glial cell activity, congenitic immune response, and TNF-NF-B signal transducation.
Tyrosine kinase Src controls the activity of small glial cells by increasing the production and secretion of TNF, and further tests by the team have shown that drinking alcohol increases TNF production through the Src-NF-B pathline, triggering small glial cell activity.
Next, the researchers used mouse behavior experiments to show that alcohol intake causes anxiety-like behavior in the form of small glial cell dependence, while blocking the transfer of TNF signals in small glial cells can inhibit anxiety-like behavior caused by alcohol intake.
the number of major proteins involved in excitable synapses in the pre-frontal cortical cortical layer of the brain and the number of excitable synapses decreased significantly.
this is because alcohol induces TNF signal transductivity, increasing the phagocytostyle activity of small glial cells, thereby reducing the number of synapses in the pre-cortical cortical layer.
, the study showed that alcohol enhances the activity of tyrosine kinase Src, thereby increasing the production of NF-B-dependent TNF, triggering small glial cells to be active.
the activity of small glial cells reduces synapses between neurons in the pre-cortical cortical layer of the brain, inhibits nerve transductivity, and causes anxiety.
Src inhibitors inhibit alcohol-induced anxiety-like behavior, suggesting that targeting the Src-NF-NF-B-TNF path path in small glial cells can prevent alcohol-induced anxiety.
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