Sci Rep: Targeted therapy significantly inhibits breast cancer tumor growth in mice

June 2, 2020/PRNewswire
BIOON/ -- A team of researchers led by Wole Soboyejo, dean of the Worcester Institute of Technology (WPI), has identified a targeted drug that can reduce the size ofin hard-to-treat micebreast cancertumors without causing toxic side effects usually associated with conventional chemotherapyresearchers in an article published in Scientific Reports said a molecular identification unit was attached to drugs specifically targeting "three-negative" breast cancer tumors, which typically do not respond to targeted treatmentsThese targeted drugs eliminate or narrow theof breast cancertumors in mice in laboratory experimentsAnd no toxic side effects were observed in the experiment"When injected into the bloodstream, only a small fraction of traditional chemotherapy drugs reach the tumor," Soboyejo said"It usually takes a relatively high concentration of traditional anti-cancer drugs to have a therapeutic effect on the tumorAs a result, this concentration is often toxic to other cellsIn our study, targeted drugs were more effective in reducing and eliminating three-negative breast tumors in miceThey also eliminated theoftumors without toxicityPicture Source: https://cn.bing.com
breast cancer is the most common cancer in womenChemotherapy kills fast-growing tumor cells by injecting powerful drugs into the patient's body, but this treatment usually produces toxic side effectsThe goal of targeted therapy is to reduce side effects by providing chemotherapy drugs directly tocellsbreast cancerThese drugs are found and bound to specific cellular structures called receptorsthree common receptors that are expressed on the surface ofcells inbreast cancer are HER2, a growth factor, and estrogen and progesteroneMost breast cancer treatments target HER2 receptorsHowever, 10 to 17 per cent of breast cancers lack HER2, estrogen and progesterone receptorsThese "triple negative" breast cancers are more common among young women, African-American women and African womenSoboyejo was inspired by a relative's battle with breast cancer, having previously studied the yellow hormone release hormone (LHRH) as a target mechanism to transfer magnetic nano
particles to the of the breast tumor The study found that targeted magnetic nano
particles could improve the imaging of the mammary tumor of naked mice, a laboratory mouse LHRH is a naturally occurring hormone in mammals This is necessary for reproduction recently, Soboyejo began studying LHRH as a target mechanism for chemotherapy drugs His work was funded by WPI and the Pan-African Materials Institute of the African University of Science and Technology in Abuja, Nigeria, which was funded by the World Bank in the study, the researchers attached the chemotherapy drug yewol to LHRH They also attached a natural substance with anti-cancer properties to LHRH Both combinations are used to treat triple-negative breast cancer cells and Soboyejo's team hopes to continue to study LHRH-targeted nano
particles and therapeutic drugs and use them in clinical trials breast cancer patients The team is also looking at other targeted drugs and nanoparticles used to detect and treat other tumor it's important that we locate triple-negative breast cancer in mouse models However, I think this approach is also of great significance for targeted cancer treatment in general Soboyejo said (Bio ValleyBioon.com) References: Research Team Shrinks breast cancer cancer s in mice with targeted with the J D Obayemi et al, LHRH-Conjugated Drugs as Targeted Therapeutic Sing agentfor the Specific Targeting and Local Family of Triple-Up Breast, DOI: 10.1038/s41598-020-64979-15