SCI Rep: new research reveals the pathogenesis of Alzheimer's disease

September 18, 2019 / BIOON / -- in a recent study, neuroscientist Jack jhamandas from the University of Alberta solved another mystery of Alzheimer's disease, which brings us one step closer to curing the disease In a study published in the journal scientific reports, the authors found that mice with Alzheimer's disease can significantly improve their memory by continuously injecting them with a special peptide "In mice treated with drugs, we found that the deposition of amyloid plaques began to decrease, as did brain inflammation." (image source: www Pixabay Com) the discovery is based on a previously discovered compound called AC253 Previous studies have shown that AC253 can block the toxic effect of amyloid protein However, although AC253 has been shown to prevent the accumulation of amyloid β, it is not effectively absorbed by brain cells, on the contrary, it will be rapidly degraded in the blood In addition, due to the complex chemical structure of AC253, there are many technical problems in the design of oral drugs In this regard, the author attempts to cut AC253 into short peptides and study whether it can also block the accumulation of amyloid β Through the mouse model test, the author found two short derivatives of AC253, which have the same ability as AC253 Furthermore, the author found similar drug molecules that can be used to treat hypertension or cholesterol through computer modeling and artificial intelligence technology, and hoped to be used in the development of new drugs In this regard, jamandas is very optimistic Source of information: new piece of Alzheimer's puzzle found original source: Rania Soudy, Ryoichi Kimura, aarti Patel, Wen Fu, Kamaljit Kaur, David Westaway, Jing Yang, Jack jhamandas Short acylin receiver against against factors improve memory defects in Alzheimer's disease mouse model Scientific reports, 2019; 9 (1) DOI: 10.1038/s41598-019-47255-9