Sci Immunol: Special immune molecular signals may promote the host body's antibody-dependent cytotoxic response to herpes simplex virus.

September 16, 2020 // -- A recent publication in the international journal Science ScienceLogy entitled "HVEM signaling promotes the life of the antibody-dependent cellular cytoxicity (ADCC) vaccines to her In the pes simplex viruses" study, scientists from institutions such as the Albert Einstein College of Medicine found a special signal that a cytotoxic vaccine that promotes protective antibody dependence reacts to the herpes simplex virus.
photo source: Wikimedia researchers say antibodies against viruses produced when the body is infected or vaccinated can neutralized viral or antibody-dependent cytoxicity (ADCC, antibody-dependent cellular cytoxic) to protect the host; HSV's glycoprotein D (gD) is not only necessary for the virus to enter the host and spread between cells, but also binds to the host body's immunomodulation molecule called HVEM, thus blocking its interaction with the ligation.
Natural infections in the body mainly cause the production of neutral antibodies targeting gD, but sub-unit protein vaccines designed to induce this reaction have now failed in clinical development; The researchers conducted these studies to test the hypothesis that gD interferes with ADCC through the involvement of HVEM, compared to wild controlled mice, by mediating the cytototoxic effects of antibody dependence (ADCC) by activating the expression of Fc gamma subjects (Fc-Rs). /? Levels of HSV-specific IgG2 antibodies, which are directly related to the activation of Fc-R and ADCC, decrease significantly in mice.
, the researchers were vaccinated against another HSV candidate vaccine (dl5-29) or an unrelated vector of fable oral inflammatory disease. /? Similar drops in ADCC were observed in mouse bodies; /? Not only does the passive transfer of immune serum in mouse organisms not protect wild mice, but the immune serum transfer from wild mouse bodies vaccinated with gD-2 does not protect Hvem? /? Mice; from Hvem? /? Immune cells in mice often have Fc-R-activated damage, and instead, adding gD proteins or anti-HVEM antibodies to activation trials in in-body mice or humans with Fc-R may inhibit the above-mentioned immune response.
researchers say the findings reveal a new role that scientists have not previously recognized in HVEM signaling, which plays a significant role in generating and mediating ADCC and additional HSV immune escape strategies.
() Original source: Clare Burn Aschner, Lip Nam Loh, Benjamin Galen, et al. HVEM signaling promotes lifesasting antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses, Science Immunology 14 Aug 2020: Vol. 5, Issue 50, eaax2454 doi:10.1126/sciimmunol.aax2454.