SCI Immunol: new achievements in allergy research! Brush cells in the nasal cavity may secrete pro-inflammatory lipid molecules

February 8, 2020 / BIOON / -- recently, a research report published in the international journal Science immunology, researchers from Brigham women's Hospital and Harvard Medical School found brush cells in the nasal cavity of mice through research Cells) can secrete pro-inflammatory lipids In this paper, the researchers describe the characteristics of this chemical sensing cell in the mouse nasal cavity and the molecular mechanism of its function Photo source: uliyeva et al., SCI Immunol 5, eaax7224 (2020)
In the past few centuries, with the increase of stimulants caused by human activities, the sensitivity of human beings to substances in the environment has begun to deteriorate Scientists studying allergic reactions have learned a lot about the process of allergic reactions, but they don't know exactly what induced allergic reactions In this study, researchers found chemistry in the nasal cavity of mice It is also found that these cells can produce special chemicals to promote inflammation In order to further understand the biological process of inducing the body's response to stimuli, the researchers studied the chemoreceptor brush cells around the nasal cavity and respiratory tract of mice In order to further study the function of these cells, the researchers contacted these brush cells with a variety of known stimuli and observed their response Previous studies have shown that immune cells in the blood can produce lipid molecules called cysteinyl leukotriene, which plays a key role in the development of allergies and sensitivity reactions After careful analysis of brush cells in the nasal cavity of mice, the researchers found that brush cells can also produce this lipid molecule, but only when exposed to specific mold, dust mite protein or energy carrier Adenosine triphosphate: after testing cells in living mice, the researchers found that exposure to the same stimulants caused swelling of the nasal tissue If these brush cells were removed from the nasal cavity of the tested mice, the mice would experience slight inflammation In the next step, researchers will carry out similar research in human nasal brush cells If similar results can be obtained, researchers will turn off the response of brush cells to stimulants in extreme cases or remove all of them if possible Of course, the researchers also plan to further study brush cells in the later stage, so as to further analyze and clarify the various types of human allergies Factor Original sources: saltanat ualiyeva, Nils Hallen, Yoshihide Kanaoka, et al Airway brush cells generate cysteinyl leukotrienes through the ATP Sensor P2Y2, science immunology 17 Jan 2020: Vol 5, issue 43, eaax7224 doi: 10.1126/sciimmunol.aax7224