Sci Adv's team discovered a novel electrical signal that maintains circadian rhythms

On September 2, 2022, luo Donggen's team from the Beijing University Of Sciences, the McGovern Brain Research Institute, the Center for Quantitative Biology, and the Joint Center for Life Sciences published an extra-clock ultradian brain oscillator sustains circadian timekeeping research paper at Science Advances, reporting a new type of electrical signal and its neural mechanism that maintains circadian rhythms.

Luo Donggen's team for the first time developed a method that can record the fine electrical activity of all Drosophila clock neurons [3], in this study, the team further developed the four-electrode diaphragm clamp recording technique [4] of the Drosophila brain clock neurons, which observed that the clock neurons produced a synchronized rhythmic action potential release in the whole brain, and found that this synchronous release was completely dependent on synaptic input

The study identified the first group of oscillator neurons within the drosophila brain and revealed their neural mechanisms in maintaining circadian rhythms (Figure 1

Figure 1: XCEOs maintain circadian rhythms

Researcher Donggen Luo is the corresponding author of this article; Dr.

Luo Donggen Laboratory has developed international cutting-edge neuroelectrophysiology techniques (including four-electrode diaphragm clamp records for living Drosophila brains) using a variety of model animals such as fruit flies, mice and non-human primates, combined with cutting-edge technologies such as brain connective groups, molecular genetics, optogenetics and two-photon calcium imaging, to reveal the basic laws

Original link:

http://doi.

Model Maker: Eleven

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