 Home > Active Ingredient News > Antitumor Therapy > Sci Adv: The "three brothers" of Parkinson's disease, cancer, and type 2 diabetes are originally in the same line

Sci Adv: The "three brothers" of Parkinson's disease, cancer, and type 2 diabetes are originally in the same line

 Last Update: 2021-04-17
 Source: Internet
 Author: User

Tags

antihistamine drugs list

what viscosity science

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

When the cell is under pressure, a chemical alarm will sound, which initiates a series of activities to protect the core part of the cell.

Salk researchers found a direct connection between the main sensors of cellular stress and Parkin itself.

Science Advances

Parkin's job is to remove mitochondria that have been damaged by cellular stress so that new mitochondria can take their place.

Shaw's laboratory is known for its work in the areas of metabolism and cancer, and it has spent years studying in depth how cells regulate the cell's more general cell cleaning and recycling process, namely autophagy.

The AMPK enzyme controls autophagy by activating an enzyme called ULK1, which is highly sensitive to a variety of cellular stresses including mitochondrial damage.

In order to confirm the correctness of the research results, the research team used mass spectrometry to accurately reveal the position where ULK1 attaches the phosphate group to Parkin.

Push Push measure which might be "warning" signal is sent to Parkin by AMPK ULK1, let Parkin after the first wave of strikes to check the damage mitochondria and triggers the destruction of those severely impaired mitochondrial function and can not be restored if necessary.

Mutations in the phosphorylation site of ULK1 in arkin, inherited AMPK or ULK1 depletion, or drug-induced ULK1 inhibition, will cause the delay of Parkin activation, as well as defects in the detection of Parkin function and downstream mitotic events.

At time 0, Parkin protein (green signal) and mitochondria (red signal) are located in different parts of the cell (left image), but co-localize with mitochondria after 60 minutes (right image)

Maximum Parkin activity depends on the Parkin phosphorylation of ULK1

These findings have broad implications.

AMPK is the core sensor of cell metabolism.

Changes in metabolism and mitochondrial health are critical in cancer, diabetes, and neurodegenerative diseases.

sciencemag.

sciencemag.
org/content/7/15/eabg4544" target="_blank" rel="noopener">AMPK / ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy

in this message

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.