Sci Adv: Study reveals structure in various parts of the brain

, July 2, 2020 /PRNewswire/ --- -- In a new study, researchers at the Karolinska Institute in Sweden and the KTH Royal Institute of Technology have developed a new brain map based on mapping brain tissue to brain regions based on molecular structureThe study was published in the journal Science advancemany of the maps currently used to describe the human and mammalian brains are based on differences in the way neuronal tissue sedituated or the distribution of neurotransmitters(photo source:current research examines whether there is a more independent way to define brain maps based on data and facts"To achieve this mapping, we used a method called spatial transcriptional histology, which allows us to capture molecules that encode cell identity and function," explains Dr Meletismethod of extracting RNA molecules was developed by Professor Lundeberg of KTH to identify the exact location of molecules in brain tissueAlthough the brains of mice are small, nearly 35,000 large measurements have been completed, with a total of 35,000 different measurement points
which allowed researchers to reconstruct virtual 3D maps of the entire mouse brain using data from more than 15,000 genes active in each regionstudies have shown that detailed maps can be created without previous knowledge and experience in neuroanatomyThe study provides a basis for researchers to compare studies and map the brains of other speciesthe method is also useful for mapping the human brain, for example, by enabling scientists to identify brain molecular changes associated with certain diseases"We know that all imbalances in the brain can lead to mental or neurological disorders, " says Dr Meletis"In the search for new treatments, knowledge of molecular differences between brain regions and how they affect neuronal function will be critical." (Bio Valley Bioon.com)source:Researchers develop new atlas for mapping brain regions
original origin: Ortiz, C., et al (2020) MolecularAtlas of the adult mouse brain.
Science Advances.
doi.org/ 10.1126/sciadv.abb3446.