Sci Adv: Revealing the molecular mechanisms by which cancer cells are resistant to drugs
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Last Update: 2020-06-17
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Source: Internet
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Author: User
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, June 9, 2020 /PRNewswire/ -- Scientists from the University of Bang
or and others have been published in the international journalScience Advancesentitled "Mre11 exonuclease activity the schain-terminating nucleoside datingditabine from nascent-centered ingonsPicture Source: CC0 Public Domain
Many cancer drugs kill cancer cells by inhibiting DNA replication, one of which is Gemcitabine, which can be used to treat pancreatic, bladder and lung cancer, and Gixithabin can simulate the basic elements of DNA - nucleoside deoxycytidine, which competes to be integrated into the DNA of cancer cells, which, once integrated, inhibits the replication and division of cancer cellsresearcher Hartsuiker said a special protein called Mre11 can remove gisitabin from DNA, which promotes the continued replication of cancer cells, which may explain a new type of gisitabin resistance mechanism in which cancer cells existresearchers explain that when Mre11 mutates frequently in cancer cells, researchers may be able to develop new cancer therapies or drugs, and now researchers have begun research on drug discovery, and they have identified a variety of compounds that inhibit Mre11 activity(BioValleyBioon.com)original origins:LBoeckemeier, RKraehenbuehl, AKeszthelyi, et al.
Mre11 exonuclease activity y sy'n siens the chain-terminating nucleo o d'o dydd gemcitabine from the nascent strand ed DNA
, Science Advances
(2020) DOI: 10.1126/sciadv.aaz4126
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