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September 11, 2020 /--- In a recent study, scientists at cold spring harbor laboratory (CSHL) and Stanford University revealed the neurological mechanisms of brain circuits that regulate insomnia when people are stressed.
their study in mice linked neuron connections that trigger insomnia to changes in the immune system caused by stress, which in turn weakened the body's defenses against multiple threats.
the study was published on September 9, 2020 in the journal Science Advance.
stress-induced insomnia is a well-known phenomenon," said Jeremy Borniger, an assistant professor at the University of London (Photo: www.pixabay.com).
in the clinical field, it has long been known that patients who are chronically stressed are more likely to develop other types of diseases and have relatively poor treatment outcomes.
" like many aspects of the body's stress response, these effects are thought to be driven by the stress hormone cortisol.
mice, they found that signals from brain cells that release hormones have a strong effect on neurons that cause insomnia.
interfere with this connection, even if the mice are stressed, and artificial simulations of sensitive cells immediately awaken the sleeping animals.
: "This seems to be a very sensitive switch, because even weak stimulation of the circuit can lead to insomnia.
found that the same connections also worked for the immune system.
stress greatly disrupts the abundance of certain immune cells in the blood and disrupts the signaling pathways within them, and the team was able to reproduce these changes only by stimulating the same neurons that link stress to insomnia.
the mechanism opens the door to a deeper understanding of the consequences of stress, not only for healthy people but also for disease, said Borniger, a research executive.
(bioon.com) Source: The neurons that stress connect, insomnia, and the original source of the immune system: "Hypothalamic circuitry underlying stress-induced insomnia and peria immunosuppression" Science Advances (2020). advances.sciencemag.org/lookup . . . 1126 / sciadv.abc2590.
