Schizophrenia is related to excessive hydrogen sulfide in the brain

Schizophrenia is a group of serious psychosis with unknown etiology, which usually starts slowly or subacute in the young and middle-aged Clinically, it is often manifested as syndrome with different symptoms, involving many obstacles such as sensory perception, thinking, emotion and behavior, as well as uncoordinated mental activities Patients generally have clear consciousness and normal intelligence, but some patients will have cognitive impairment in the process of disease The course of the disease is generally prolonged, showing repeated attack, aggravation or deterioration Some patients eventually appear recession and mental disability, but some patients can maintain recovery or basic recovery after treatment A team from the Japanese Institute of physics and chemistry and the University of Tokyo recently found that excessive hydrogen sulfide production in the brain is related to the pathology of schizophrenia Using schizophrenia related and unrelated mouse strains, the team found that schizophrenia was associated with an increase in MPST, an enzyme that produces hydrogen sulfide, by proteomic analysis In addition, the analytical data of human samples also showed that the brain of schizophrenics produced excessive hydrogen sulfide The study also found that the expression level of MPST protein in the brain after death was related to the severity of clinical symptoms before death The expression of MPST gene in hair is expected to be a highly sensitive biomarker The reason of hydrogen sulfide excess may be the compensatory response of brain to inflammation and oxidative stress during development The results also show that the excessive production of hydrogen sulfide will lead to the decrease of energy metabolism and the density of dendritic spines, which will increase the risk of schizophrenia (BIOON Com)