Schizophr Bull: Abnormalities in the ventral striatal cortex may reflect the risk of 22q11.2 deletion syndrome

22q11.
2 deletion syndrome (22q11.
2DS) is a genetic neurodevelopmental disorder and one of the largest known risk factors for mental illness
.

Previous studies on patients with mental illnesses without missing have found that dopaminergic dysfunction in the striatum and the connection disorder of the striatal cortex system are important mechanisms for the emergence of psychosis

22q11.

Tepper Á et al.
explored the connections of the striatum in patients

 The study used resting functional MRI to examine the functional connectivity of the striatum in patients with
22q11.

2DS .
Using a 2 × 2 factorial design includes 125 embodiment (55 healthy controls and 28 patients without a history of psychiatric 22 q11.

 The study used resting functional MRI to examine the functional connectivity of the striatum in patients with

22q11.

2 DS- related functional connectivity changes in the striatum

22q11.
2 DS- related functional connectivity changes in the striatum

Psychiatric-related changes in functional connectivity of the striatum
.

Note : DCP , dorsal putamen ; iVC , lower ventral caudate nucleus ; sVC, upper ventral caudate nucleus

Psychiatric-related changes in functional connectivity of the striatum

The interaction between psychosis and 22q11.

2DS .
Functional connectivity of the striatal cortex .

The interaction between psychosis and 22q11.
2DS .
Functional connectivity of the striatal cortex .
Cortical areas where significant interactions are found are highlighted .
The right column shows the visual representation of the interaction between psychosis and the 22q11.

 Consistent with the previous results of psychiatric patients
without 22q11.
2DS , the study found that in both groups of patients, there was a dorsal to ventral gradient connecting the striatum cortex from the bottom to the top associated with psychosis .
In addition, 22q11.
2DS was associated with abnormal functional connectivity of the ventral striated cortical network, while no significant difference was found in the dorsal system
.

The study investigated a genetic change associated with a very high risk of psychosis, namely the functional connection of the striatal cortex associated with the loss of 22q11.
2 .
The study found dysfunction of the ventral striatal cortex system associated with the absence, which may explain the higher risk of psychosis in this population .
No significant difference was found in the dorsal striated cortex system of 22q11.
2DS patients
.
Changes in the dorsal striated cortex system only appeared in subjects with a known history of mental illness, and this group of patients had abnormal connections in the ventral system
.

The study investigated a genetic change associated with a very high risk of psychosis, namely the functional connection of the striatal cortex associated with the loss of 22q11.
2 .
The study found dysfunction of the ventral striatal cortex system associated with the absence, which may explain the higher risk of psychosis in this population .
No significant difference was found in the dorsal striated cortex system of 22q11.
2DS patients
.
Changes in the dorsal striated cortex system only appeared in subjects with a known history of mental illness, and this group of patients had abnormal connections in the ventral system
.
Changes in the dorsal striated cortex system only appeared in subjects with a known history of mental illness, and this group of patients had abnormal connections in the ventral system
.

The results of this study show that ventral striatal cortex network dysfunction in people with high genetic risk of psychosis, and striatal cortex system dysfunction in psychotic patients is more common
.
Abnormalities in the ventral striatal cortex system observed in individuals with high genetic risk of psychosis may therefore reflect a marker of disease risk
.

The results of this study show that ventral striatal cortex network dysfunction in people with high genetic risk of psychosis, and striatal cortex system dysfunction in psychotic patients is more common
.
Abnormalities in the ventral striatal cortex system observed in individuals with high genetic risk of psychosis may therefore reflect a marker of disease risk
.
The ventral striatal cortex network dysfunction in people with high genetic risk of psychosis is more common in patients with psychosis
.
Abnormalities in the ventral striatal cortex system observed in individuals with high genetic risk of psychosis may therefore reflect a marker of disease risk
.

Original source

Original source

Tepper Á, Cuiza A, Alliende LM, et al.
Functional Dysconnectivity in Ventral Striatocortical Systems in 22q11.
2 Deletion Syndrome [published online ahead of print, 2021 Dec 21].
  Schizophr Bull .
2021;sbab139.
doi:10.
1093/schbul/sbab139

Tepper Á, Cuiza A, Alliende LM, et al.
Functional Dysconnectivity in Ventral Striatocortical Systems in 22q11.
2 Deletion Syndrome [published online ahead of print, 2021 Dec 21].
  Schizophr Bull .
2021;sbab139.
doi:10.
1093/schbul/sbab139 Schizophr Bull

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