Russia implants aigrass gene into chrysanthemums to extract artemisinin

researchers at the Institute of Bioorganic Chemistry of the Russian Academy of Sciences have proposed a new method for obtaining artemisininThey successfully developed Russia's first home-grown antimalarial drug by transplanting the aigrass gene into chrysanthemums and extracting artemisinin, a natural antibiotic that plays an important role in the treatment of malariaThe findings are published in the journal PlantMoscow and the Caucasus have recently been recorded as malaria-affected areas as a result of population movementsScientists say warming will increase the spread of mosquito-borne diseases, which will accelerate the spread of malaria in RussiaBut Russia has never produced artemisinin and any other antimalarial drugs, and treatment can only be treated with foreign drugs, and is extracted only from wild plants, not on a large scaleMost modern drugs contain active media that are either themselves or separated from plants, says Sergei Dolgov, Ph.Din biology, who heads the institute's plant genome expression systems and transformation laboratoryAigrass extract does work, but the annual grass usually grows in rocky or grassland areas and yields very little in other climatic conditionsIn order to meet the raw materials needed for large-scale drug production, attention must be paid to modern molecular biology methodsThe researchers' core idea is to transfer the artemisinin metabolism pathway gene to another host plantThe study found that extracting artemisinin from chrysanthemums is a good way to do itChrysanthemum contains a high natural terrier compound and a natural bioactive compound with a wide medicinal value, transplanting the aigrass gene to chrysanthemum, with the help of gene transplantation, artemisinin is produced in chloroplast, and then covers the entire leafTypically, artemisinin is produced only in the hairy form of the grass, i.ethe ai grass skin cells, so the yield is lowStudies have shown that this method can greatly increase artemisinin production The amount of artemisinin that can be used in awe does not exceed 1% of the dry weight of the leaves, which is not sufficient for large-scale clinical production The laboratory of Professor Alexander Weinstein of the Hebrew University of Jerusalem, Israel, has identified four genes: ADS, CYP71AV1, DBR2 and CPR These genes are all encoded as enzymes in the artemisinin anabolic pathway After transplanting them into a new environment and adding other genes, artemisinin production is expected to reach commercially feasible levels It is reported that the first successful cultivation of genetically modified chrysanthemums has been planted in greenhouses for the next step of scientific research The presence of artemisinin was confirmed by high-efficiency liquid chromatography and thin-layer chromatography researchers at the Institute of Bioorganic Chemistry of the Russian Academy of Sciences proposed a new method for obtaining artemisinin They successfully developed Russia's first home-grown antimalarial drug by transplanting the aigrass gene into chrysanthemums and extracting artemisinin, a natural antibiotic that plays an important role in the treatment of malaria The findings are published in the journal Plant Moscow and the Caucasus have recently been recorded as malaria-affected areas as a result of population movements Scientists say warming will increase the spread of mosquito-borne diseases, which will accelerate the spread of malaria in Russia But Russia has never produced artemisinin and any other antimalarial drugs, and treatment can only be treated with foreign drugs, and is extracted only from wild plants, not on a large scale Most modern drugs contain active media that are either themselves or separated from plants, says Sergei Dolgov, Ph.D in biology, who heads the institute's plant genome expression systems and transformation laboratory Aigrass extract does work, but the annual grass usually grows in rocky or grassland areas and yields very little in other climatic conditions In order to meet the raw materials needed for large-scale drug production, attention must be paid to modern molecular biology methods The researchers' core idea is to transfer the artemisinin metabolism pathway gene to another host plant The study found that extracting artemisinin from chrysanthemums is a good way to do it Chrysanthemum contains a high natural terrier compound and a natural bioactive compound with a wide medicinal value, transplanting the aigrass gene to chrysanthemum, with the help of gene transplantation, artemisinin is produced in chloroplast, and then covers the entire leaf Typically, artemisinin is produced only in the hairy form of the grass, i.e the ai grass skin cells, so the yield is low Studies have shown that this method can greatly increase artemisinin production The amount of artemisinin that can be used in awe does not exceed 1% of the dry weight of the leaves, which is not sufficient for large-scale clinical production The laboratory of Professor Alexander Weinstein of the Hebrew University of Jerusalem, Israel, has identified four genes: ADS, CYP71AV1, DBR2 and CPR These genes are all encoded as enzymes in the artemisinin anabolic pathway After transplanting them into a new environment and adding other genes, artemisinin production is expected to reach commercially feasible levels It is reported that the first successful cultivation of genetically modified chrysanthemums has been planted in greenhouses for the next step of scientific research The presence of artemisinin was confirmed by high-efficiency liquid chromatography and thin-layer chromatography 0
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