Rice smut research team reveals new mechanism of rice smut inhibiting rice immunity

Nanhu News Network (Correspondent Chen Xiaoyang) Recently, Huang Junbin's research group from the School of Plant Science and Technology of our school published a research paper entitled "A secreted fungal effector suppresses rice immunity through host histone hypoacetylation" online on New Phytologi.

Rice smut is one of the most important diseases in rice production in the world, and is widely distributed in more than 40 rice-growing countries in Asia, America, Africa and Euro.

During the interaction between plants and pathogens, plants themselves have evolved an effective innate immune system to resist infection by pathogens, mainly including PTI (PAMP-triggered immunity) and ETI (Effector-triggered immunity) two immune leve.

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The researchers first jointly analyzed the secretome and transcriptome data of Aspergillus oryzae, and selected 19 candidate secretory proteins whose expression was up-regulated in the early infection stage for gene knocko.

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In conclusion, Aspergillus oryzae can secrete a toxic effector protein UvSec117 into the host cell, which interacts with the rice histone deacetylase OsHDA701, and recruits a large amount of OsHDA701 to the nucleus through the nuclear localization signal of UvSec11 The interaction of OsHDA701 can enhance the deacetylation activity of OsHDA701 and reduce the acetylation level of rice histone H3K9 from two aspects, thereby interfering with the activation of defense genes and host immuni.

Chen Xiaoyang, a doctoral student at the School of Plant Science and Technology, is the first author of the paper, and Associate Professor Zheng Lu is the corresponding auth.

Reviewer: Zheng Lu

【English summary】

Histone acetylation is a critical epigenetic modification that regulates plant immuni.

Here, we identified a secreted protein, UvSec117, from the rice false smut fungus, Ustilaginoidea virens, as a key effector that can target the rice histone deacetylase OsHDA701 and negatively regulates rice broad-spectrum resistance against rice pathoge.

Host-induced gene silencing (HIGS) of UvSec117 promotes rice resistance to.

This is the first direct evidence demonstrating that a fungal effector targets a histone deacetylase to suppress plant immuni.

Paper link : https://n.