Rhodium (Ⅲ), a new metal complex developed by Hong Kong Baptist University, can treat skin cancer

Dr madilong pointed out that the newly developed complex is expected to further develop into an effective anti-tumor drug, and scholars from Hong Kong, Macao and Taiwan will work together to develop a new metal complex for skin cancer Ma Dilong, assistant professor of Chemistry Department of Hong Kong Baptist University, together with Liang chongheng, associate professor of Chinese Medical Research Institute of Macau University and experts from Kaohsiung Medical University of Taiwan, has successfully developed a new metal complex "rhodium" for the first time in the world (III) "the team's experiments in mice showed that rhodium (III) complex treatment can reduce malignant tumors by about 60%, without killing healthy cells." After dimerization, STAT3 signal protein can cause various cancers (including skin cancer) in human body Madiolone and the team proposed to inhibit the activity of STAT3 dimerization, which has the opportunity to inhibit skin cancer After two years, the team screened rhodium (Ⅲ) as the main inhibitor from 35 metal complexes The team used two groups of mice with melanoma skin cancer to do the experiment This kind of cancer is the most serious skin cancer with the highest mortality The results showed that the compound could inhibit the growth of malignant tumor in mice More importantly, after the mice received the treatment of rhodium (Ⅲ) complex, the malignant tumor was significantly reduced, and there was no special change in weight, which proved that rhodium (Ⅲ) complex could not kill other healthy cells, but also inhibit the proliferation of blood vessels near the tumor The results show that rhodium (Ⅲ) complex can effectively inhibit the growth of melanoma in mice "The results of this study are very important because inhibition of the intracellular carcinogenic STAT3 activity has the opportunity to effectively inhibit the growth of melanoma," madilong said Our team is the first in the world to find that rhodium (Ⅲ) complex can directly inhibit the dimerization of STAT3 protein Our experiments show that rhodium (Ⅲ) complex can be effectively used to fight melanoma in animals, laying an important foundation for the development of human anti-cancer drugs in the future " Rhodium (Ⅲ) complex can be used to treat different kinds of cancer In the future, the team will continue to improve the structure of rhodium (Ⅲ) complex to improve its anti-cancer effect In this study, the immersion team was mainly responsible for the synthesis of metal complexes, while the University of Macau was responsible for the collection of biological test data of metal complexes, and finally the selected metal complexes were sent to Kaohsiung Medical University in Taiwan for testing The team's research paper rhodium, a complex that directly inhibits STAT3 dimerization, has been published in the International Journal angelwandte Chemie (International Edition, 2014), and has been selected as a "very important paper" by the editors (by Pumi net) reprint please note: Pumi net » Angewandte Chemie: the immersion university has developed "rhodium" to treat skin cancer