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Rheumatology: The 3 endotypes of adult Still's disease and how do they differ?

 Last Update: 2022-10-11
 Source: Internet
 Author: User

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Objectives: This study aimed to analyze the immune cell profile of adult Still's disease (AOSD) and stratify disease-related endotypes

Methods: A total of 95 untreated AOSD patients and 66 healthy controls (HCs) were included in the study

AOSD patients were classified by an unbiased hierarchical cluster analysis based on circulating immune cells

Results: The proportion of neutrophils and CD8 ⁺ T cells was significantly increased in AOSD patients, while the proportion of monocytes, natural killer cells and CD4 ⁺ T cells decreased (all p

Unbiased hierarchical cluster analysis divided 95 cases of AOSD into three groups: group 1 with the highest percentage of neutrophils (Neu-dominant group), group 2 with the highest percentage of monocytes (mono-dominant group), and group 3 with CD8 ⁺ The highest percentage of T cells (CD8-dominant group)

Patients in group 3 had the highest systematic scores at diagnosis and were more likely to have pulmonary infiltrates, pericarditis, splenomegaly, and poorer response to treatment

Relevant studies have shown that the CD4/CD8 ratio was negatively correlated with the systematic scores of AOSD patients and positively correlated with treatment response (p = 0.

Conclusions: Hierarchical cluster analysis of peripheral immune cells classified AOSD into three disease-related endotypes

literature:

Guo R, Liu X, Li Y, et al.

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