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Objective: To determine an ultrasound (US) scanning protocol for the diagnosis of gout and pyrophosphate arthropathy (CPPD) in patients with acute mono/oligoarthritis of unknown etiology to improve diagnostic accuracy
METHODS: Acute mono/oligoarthritis patients were consecutively enrolled and required joint aspiration in the most clinically involved joint (target joint)
RESULTS: A total of 161 subjects (32 patients with gout, 30 patients with CPPD, and 99 disease controls) were included in the study
US results were highly specific for gout (0.
Ultrasound assessment of two joints bilaterally (gout: knee, MTP1js; CPPD: knee, wrist) + target joint has excellent diagnostic sensitivity (gout: 0.
This targeted ultrasound scanning protocol yielded higher diagnostic accuracy compared with ultrasound assessment of the target joint (gout, AUC: 0.
CONCLUSIONS: The targeted ultrasound scanning protocol of bilateral two joints + target joints (unless knee, MTP1j, or wrist) showed excellent accuracy in diagnosing crystalline arthritis in patients with acute mono/oligoarthritis ( >90%)
Source:
Cipolletta E, Filippucci E, Abhishek A, et al.