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OBJECTIVE: There is increasing evidence that vascular disease is involved in the pathogenesis of knee osteoarthritis
.
Popliteal artery wall thickness can be used as a surrogate marker for atherosclerosis
.
The team investigated the relationship between popliteal artery wall thickness and knee cartilage volume in symptomatic knee osteoarthritis patients
.
Methods: This prospective cohort study analyzed 176 participants from a randomized placebo-controlled trial to investigate the effect of atorvastatin on structural progression of knee osteoarthritis
.
Participants underwent magnetic resonance imaging (MRI) of the study knee at baseline and at two-year follow-up
.
Popliteal artery wall thickness and tibial cartilage volume were measured with MRI using validated methods
.
The upper quartile of tibial cartilage volume loss rate was defined as rapidly progressive
.
RESULTS: At baseline, a 10% increase in popliteal artery wall thickness was associated with a 120.
8 mm 3 (95% CI 5.
4–236.
2, p=0.
04) decrease in medial tibial cartilage volume and a 151.
9 mm 3 (95% CI 12.
1–151.
9 mm 3) decrease in lateral tibial cartilage volume.
291.
7, p=0.
03) related
.
Longitudinal results found that, after adjusting for age, sex, body mass index, tibial bone area, smoking, vigorous physical activity, and intervention group assignment, a 10% increase in popliteal artery wall thickness was associated with a 1.
14-year increase in the annual incidence of medial tibial cartilage volume loss.
% (95%CI 0.
09%-2.
20%, p=0.
03), the risk of rapid progression of medial tibial cartilage loss was 2.
28 times (95%CI 1.
07-4.
83, p=0.
03)
.
Conclusions: The results of this study support the role of vascular pathology in the progression of knee osteoarthritis
.
Targeting treatment of atherosclerosis has the potential to improve outcomes in knee osteoarthritis
.
Source:
Wang Y, Pontoh EW, Hussain SM, et al.
Association between popliteal artery wall thickness and structural progression in patients with symptomatic knee osteoarthritis [published online ahead of print, 2022 Aug 16].
Rheumatology (Oxford).
2022;keac469.
doi: 10.
1093/rheumatology/keac469
