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Rheumatology: Predictive value of the adjusted global APS score for clinical recurrence in patients with antiphospholipid syndrome, a longitudinal study

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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OBJECTIVE: To assess the effect of mean adjusted global APS total score (aGAPSS) on recurrence of clinical manifestations in patients with antiphospholipid syndrome (APS) in a retrospective longitudinal study

Methods: The study included 200 patients with APS

In patients taking vitamin K antagonists (VKA), the percentage of time spent in the therapeutic range (TTR) was calculated

Results: The mean aGAPSS value of patients with clinical recurrence was higher than that of patients without recurrence [8.

The mean aGAPSS value of patients with recurrent thrombosis was higher than that of patients with recurrent miscarriage [9.

The mean aGAPSS value of patients with arterial thrombosis was higher than that of patients with venous thrombosis [10.

In multivariate analysis, aGAPSS values >13 were associated with the highest risk of recurrence [HR = 3.

Conclusions: Data from this study support the role of regular (annual) monitoring of the aGAPSS score in predicting clinical relapse in patients with APS

Source:

Barilaro G, Esteves A, Della Rocca C, et al.

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