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Rheumatology: Low-dose rituximab is effective in refractory idiopathic inflammatory myopathy

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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OBJECTIVE: The early use of rituximab (RTX) in refractory idiopathic inflammatory myopathy (IIM) has not been well studie.

Methods: Registration-based observational data from patients with IIM receiving rituximab from 2018 to 2021 were include.

Results: A total of 42 patients (F:M=29:13) were included, with an average age (standard deviation) of 35 (±15) year.

Most patients received rituximab for refractory myositis after a median (IQR) duration of 8 (4, 18) month.

Improvements in manual muscle test (MMT-8) scores, PGA (Physician's Global Assessment), PtGA (Patient's Global Assessment), median steroid dose compared to baseline after 6 and 12 months of RTX ( p<01 for all items.

Changes in MMT-8, PGA, and PtGA scores were significantly different for both RTX dose regimens at 6 and 12 months from baselin.

Three patients in the cohort developed severe lower respiratory tract infections requiring hospitalizatio.

CONCLUSIONS: In this registry-based cohort study of refractory IIM, rituximab improved IMACS core-group measures with steroid-preserving efficacy at 6 and 12 month.

Source:

Janardana R, Amin SN, Rajasekhar L, et a.

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