Review the five major innovations of cell therapy

Scientists have successfully used human stem cells as a treatment method for hematological tumors in the past decades.

Now, 50,000 patients undergo bone marrow transplantation each year, and cell therapy has also made great progress

1.

This means that the cell source of CAR-T cell therapy always depends on the patient’s own T cells.

2.

However, in order to treat solid tumors, it is not only necessary to select the correct antigen.

3.

This approach has recently been applied to target cancer cells with mutations in the KRAS gene, which has long been considered a "drug-unavailable" target

4.

Recently, researchers have discovered that bone marrow mesenchymal stem cells can help strengthen the body’s immunity to HIV and help restore the damage caused by the disease

5.

A recent proof-of-principle study in mice showed that heart, muscle, and lung endothelial cells designed as "low immunity" can survive and successfully treat diseases in immune-competent mouse recipients
.
In addition, patients with diabetes who currently have no cure can also use pluripotent cells to grow healthy pancreatic cells to replace cells that cannot function normally in the patient's body
.
Using human induced pluripotent stem cells is closer to the way cells naturally develop in the pancreas, and is much more effective than other treatments
.
Previous experiments in a mouse model of type 1 diabetes showed that the blood sugar level of diabetic mice would be controlled within two weeks
.
However, efforts to use these cell therapies are still hampered by the ability of the patient's immune system to accept large ready-made stem cells
.

in conclusion

In summary, with the emergence of gene editing technologies such as CRISPR, the academic community has a deeper understanding of immunology, and the optimization of technologies for the production, manufacturing, transportation, storage, and processing of special biological samples and materials.
These various favorable conditions are all The development of cell therapy is being gradually promoted
.
Although from the first stem cell transplantation to the approval of the first CAR-T cell therapy for the market, to the development of cell therapy today, I believe that in the future we will definitely see the next generation of cell therapy that can make people suffering from other diseases more effective.
Many patients benefit
.

Reference source: Five Innovations in Cell-Based Therapy