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Based on these findings published in eLife on November 9, 2021, the team was able to test a retinoid therapy to improve the vision of mice with Uchel syndrome
Usher syndrome type 1F (USH1F) can cause deafness, progressive vision loss, and balance problems
Dr.
The first author of this study, Dr.
The team hopes to work with one of the companies that test these drugs to conduct clinical trials in patients with type 1F Usher syndrome to see if it can help patients by preventing continued vision loss
"About 20 years ago, the identification of a key mutation in the PCDH15 gene was a key breakthrough that helped to diagnose and screen for a certain form of Oschel’s syndrome vector.
Prior to this study, only anecdotal data on Type 1F Usher Syndrome were reported, without any detailed data analysis, and the eyes deteriorated abnormally over time
In addition, Dr.
Comparing the Usher syndrome mouse model with healthy mice, Dr.
Next, the researchers injected a type of vitamin A drug into mice with Usher syndrome to see if it improved their vision
Dr.
E.
Journal Reference :
Saumil Sethna, Wadih M Zein, Sehar Riaz, Arnaud PJ Giese, Julie M Schultz, Todd Duncan, Robert B Hufnagel, Carmen C Brewer, Andrew J Griffith, T Michael Redmond, Saima Riazuddin, Thomas B Friedman, Zubair M Ahmed.
