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| Researchers have discovered that BiIA-SG is a universal drug for effective prevention and functional cure of AIDS |
Hong Kong (HKU School of Medicine) microbiological Li Ka Shing Faculty Department of the University of AIDS led Joint Institute team found that Universal Serial bivalent broadly neutralizing antibodies BiIA-SG is expected to become an effective prevention and cure of AIDS drugs a type (HIV- 1) Drugs
.
The research team found that in experiments in non-human primates in AIDS received a single intramuscular treatment BiIA-SG before drug exposure, can be 100% effective in preventing pathogenic infections; and after using the same therapy in infected animals also Can survive 100%, and continue to completely inhibit the virus in most animals for up to two years
Hong Kong AIDS AIDS AIDS Cell Reports Cell Reports
In this study, the team used a rhesus monkey model infected with the monkey immunodeficiency virus SIV SF162P3CN (a virus with similar characteristics to HIV) and found that six of the eight rhesus monkeys without any treatment SHIV SF162P3CN evolved into monkey AIDS within two years after intravenous infection , resulting in high mortality
.
In contrast, before another group of six rhesus monkeys were infected with the virus, they received a single intramuscular BiIA-SG injection, all of which were effective in preventing viral infection, and no viral load and host-specific virus were detected.
SF162P3CN SF162P3CN AIDS AIDS
The combined antiretroviral therapy (cART, commonly known as "cocktail therapy"), which came out in 1995, greatly reduced AIDS- related mortality
.
But because patients need life-long cART treatment, the treatment costs of 37.
AIDS AIDS
In addition to BiIA-SG, the same research team at the Faculty of Medicine of the University of Hong Kong also recently demonstrated that the PD1 AIDS vaccine can induce effective effector memory CD8+ T cells in rhesus monkeys and can continue to inhibit viremia
.
The research results have been published in the June issue of PLoS Pathogens
AIDS PLoS Pathogens
Professor Chen Zhiwei, Directorof the Hong Kong University's AIDS Research Institute and the Department of Microbiology, Hong Kong University School of Medicine, who led the research, said: "The clinical development of BiIA-SG and PD1 AIDS vaccines is expected to become the first " Made in Hong Kong " functional immunotherapy to cure AIDS .
.
"Hong Kong AIDS AIDS Hong Kong AIDS
The research was mainly completed by a research team led by Chen Zhiwei, director of the Hong Kong University AIDS Research Institute and professor of the Department of Microbiology
.
Former Hong Kong University School of Medicine graduate student Dr.
Hong Kong AIDS
Related paper information: https://doi.
https://doi.
org/10.
1016/j.
celrep.
2021.
109611
