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Image: Malignant migration of breast cancer cells
Paulina Moreno-Layseca and Turku Bioimaging
Researchers have known for decades that human cells migrate from one part of the cell to another through circulating cell surface adhesion receptors
The research team of Professor Johanna Ivaska of the University of Turku in Finland has discovered a new mechanism, that is, highly aggressive triple-negative breast cancer cells use integrin circulation and in the tissues Migration
"Human cells first absorb part of the cell membrane and then recycle them to continuously renew their surface
Postdoctoral researcher Paulina Moreno-Layseca and PhD candidate Niklas Jäntti in Professor Ivaska’s research group discovered that breast cancer cells use the molecule swiprosin-1 to guide integrin adhesion receptors to this conveyor belt
By studying hundreds of breast cancer specimens, the researchers found that the high expression of swiprosin-1 molecules in tumors is significantly related to the formation of metastases and the malignancy of breast cancer
"Our findings open up a new perspective on the function of integrins and reveal new mechanisms by which cancer cells can spread throughout the body
DOI
10.
Article title
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis
