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There have been many advances in therapeutic approaches targeting pathway alterations in cancer cells
Their findings were published in the journal Science Advances under the title " Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity .
"Preclinical studies of primary cancer cells are typically performed in the presence of ambient oxygen (O2, ~21%) following tumor removal from a patient or animal," the researchers wrote
"This paper completely changes the way we need to collect tumor tissue and test for drug sensitivity," said Dr.
"Different parts of our body have almost half the amount of oxygen we find in the surrounding air," Nakshatri said
The researchers tested three different drugs on two different types of tumors
"This study now raises more questions that we need to answer," Nakshatri said
The researchers hope to study how tumors respond differently to other different oxygen levels
Nakshatri explained: "Let's say we identify a drug, as we do now in room oxygen, and then add another layer of testing in the lab, where we keep cells at physiological oxygen levels and compare whether the drug It works
