Research reveals new mechanisms for suppressing plant immunity.

On September 26, the Alberto Macho Research Group of the Shanghai Center for Excellence and Innovation in Molecular Plant Science of the Chinese Academy of Sciences published a research paper entitled A class effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity on PLoS Pathogens.
the study found new mechanisms for the pathogenicity of cyanide bacteria and explored the potential for genetically modified crop resistance.
plants, under normal growth conditions, the immune system (PTI and ETI immunity) is suppressed and does not function;
Ralstonia solanacearum is an important plant pathogen in agricultural production, infecting more than 200 plants, including potatoes, tomatoes, tobacco and other crops, causing economic losses from the disease (h so, aubergine is also known as chrysanthemum).
that the research team has identified the conservative pathogen molecule of the syringe (Wei et al. PBJ, 2018; Wei et al. Nature Comm. 2020), the discovery of a new mechanism for the pathogenicity of scum (Xian and Yu et al. Cell Host and Microbe, 2020), using the cyanide effect subprotein as a molecular probe to excavate important parts of the plant's immune system.
the study found that ripAC, an anti-bacterial effect protein, can interact with SGT1, an important regulatory protein for plant ETI immune response, and that SGT1, after being phosphatized by MAPK3/6 kinase, can promote the enhancement of NLR-mediated ETI immune response, and continuously activate MAPK3/6, so that it forms a continuous and strong immune signal transductive circuit to protect the ETI immune response.
, RipAC inhibits MAPK3/6 and SGT1, eventually making plants sick.
In addition, the effect subproteins RipaA and RipP1 can be identified by plant NLR to produce disease-resistant reactions, but in crop production, no fully resistant varieties (e.g. tomatoes) that inhibit ETI reactions have been found, and the study found that RipAC was able to suppress this reaction.
over-expression of SGT1 enhances plant resistance to bruising bacteria, and the continuous expression of phosphate SGT1 can further enhance this resistance without causing significant changes in plant development, thus demonstrating that SGT1 has the potential to respond to disease through genetically modified crops.
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