Research reveals new mechanisms for regulating blood cholesterol levels

study by Chen Wei, a researcher at the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences, found that progesterone and liposome 3 (PAQR3) play an important role in cholesterol stabilization regulation. The results of the study were published recently in Metabolism.
in the human body, plasma LDL cholesterol levels are mainly regulated by LDL lipolys, and about 70% of cholesterol is swallowed up by the body in the liver. Liver cells regulate the level of the receptor through a variety of signaling channels, in which the transdulation of the receptor is achieved mainly through the protein-converting enzyme herb protease 9. Cholesterol binds to the subject and swallows into the cells, then circulates back to the membrane to continue to function. However, protease 9 binds to the subject, altering its molecular composition, allowing the subject to degrade directly through the lysosome pathway without returning to the mass membrane.
"Our study found that specific removal of PAQR3 in the liver can lower LDL cholesterol and total cholesterol levels in the blood. PaQR3 promotes the interaction between LDL receptors and protease 9 to accelerate the degradation of receptors and reduce protein levels of receptors in the liver, thereby affecting the transport and removal of cholesterol, said Chen Wei, co-author of the paper.
findings reveal a new mechanism for PAQR3 to regulate cholesterol levels in the body, providing a new way to lower blood cholesterol levels. (Source: Huang Xin, China Science Journal)
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