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jpg" target="_blank">
jpg" target="_blank">Recently, the internationally renowned journal Phytomedicine published online the latest research results of Professor Li Xiaobo's group from Shanghai Jiaotong University School of Pharmacy entitled "Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota".
The study explained in detail the antidepressant medicinal substances and mechanism of Cistanche, and provided new ideas for the interpretation of the traditional efficacy of Cistanche and the in-depth study of the biological activity of Cistanche.
The study explained in detail the antidepressant medicinal substances and mechanism of Cistanche, and provided new ideas for the interpretation of the traditional efficacy of Cistanche and the in-depth study of the biological activity of Cistanche.
Cistanches Herba (Cistanches Herba) is a traditional Chinese medicine that has been used frequently to invigorate the kidney and yang.
It is the dry fleshy stem with phosphorus leaves of Cistanche deserticola YCMa and/or C.
tubulosa (Schenk) Wight.
Cistanche is a parasitic plant, and its hosts are desert, desert sand-fixing plants Haloxylon, Tamarix, etc.
China is one of the countries with a large area of desertified land and the most serious harm in the world.
Preventing desertification is an important issue that needs to be solved urgently in our country.
By planting Cistanche, driving the planting of sand-fixing plants such as Haloxylon ammodendron and Tamarisk, it can prevent sand and fix sand, play a role in desert control and improve the environment in the west, and it can also drive local ethnic minority people out of poverty and become rich.
It has advantages in comprehensive utilization and industrial development.
Strong social benefits.
Therefore, under the guidance of the traditional effects of Cistanche, the in-depth exploration of the new effects and uses of Cistanche has important guiding significance for the large-scale cultivation of Cistanche and the development of its industry.
The traditional Chinese medicine theory believes that it is the root of yang and the source of power; insufficient kidney yang can lead to abnormal consciousness, stagnation of qi, and symptoms of depression, loss of interest, sentimentality, etc.
; this is consistent with modern medicine.
The symptoms of bioon.
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">depression are similar, suggesting that traditional kidney-yang drugs may have potential antidepressant activity.
The research group of Professor Li Xiaobo, School of Pharmacy, Shanghai Jiaotong University, has been engaged in traditional Chinese medicine and modernization of Chinese medicine for a long time.
The previous 6 years of research confirmed that the kidney-yang Chinese medicine Cistanche has significant antidepressant activity, but its specific active substances and mechanism of action are still unclear.
It is the dry fleshy stem with phosphorus leaves of Cistanche deserticola YCMa and/or C.
tubulosa (Schenk) Wight.
Cistanche is a parasitic plant, and its hosts are desert, desert sand-fixing plants Haloxylon, Tamarix, etc.
China is one of the countries with a large area of desertified land and the most serious harm in the world.
Preventing desertification is an important issue that needs to be solved urgently in our country.
By planting Cistanche, driving the planting of sand-fixing plants such as Haloxylon ammodendron and Tamarisk, it can prevent sand and fix sand, play a role in desert control and improve the environment in the west, and it can also drive local ethnic minority people out of poverty and become rich.
It has advantages in comprehensive utilization and industrial development.
Strong social benefits.
Therefore, under the guidance of the traditional effects of Cistanche, the in-depth exploration of the new effects and uses of Cistanche has important guiding significance for the large-scale cultivation of Cistanche and the development of its industry.
The traditional Chinese medicine theory believes that it is the root of yang and the source of power; insufficient kidney yang can lead to abnormal consciousness, stagnation of qi, and symptoms of depression, loss of interest, sentimentality, etc.
; this is consistent with modern medicine.
The symptoms of bioon.
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">depression are similar, suggesting that traditional kidney-yang drugs may have potential antidepressant activity.
The research group of Professor Li Xiaobo, School of Pharmacy, Shanghai Jiaotong University, has been engaged in traditional Chinese medicine and modernization of Chinese medicine for a long time.
The previous 6 years of research confirmed that the kidney-yang Chinese medicine Cistanche has significant antidepressant activity, but its specific active substances and mechanism of action are still unclear.
This study is the first time that the total glycosides of Cistanche cistanche (TG) is the basis of its antidepressant medicinal effect.
Including 8-epicenic acid, geniposide, etc.
) ingredients can coordinately regulate the hypothalamus-pituitary-adrenal (HPA) axis, inflammation, neurotransmitter levels and other links to work together.
At the same time, the study further clarified the key role of intestinal flora in the onset of TG: On the one hand, TG can alleviate HPA axis activation and inflammation levels by regulating Erysipelotrichacea, Peptococcaceae, and a series of bacteria in the Muribculaceae family.
, And inhibit the metabolism of tryptophan-kynurenine to exert an antidepressant effect; on the other hand, hydroxytyrosol (HT), the product of TG metabolized by the intestinal flora, has also been confirmed to be one of its active substances in the body.
In addition, this study also found that TG can relieve hypothalamic-pituitary-gonad axis hypothalamus and cyclic nucleotide abnormalities in depression-like rats, which reflects the scientific connotation and advantages consistent with the traditional efficacy of Cistanche for nourishing the kidney and yang.
As a result, it explained the material basis and mechanism of Cistanche's antidepressant effect from multiple angles, provided strong support for the application and development of Cistanche in the treatment of bioon.
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">depression, and interpreted traditional Chinese medicine theories with modern medical methods.
(bioon.
com" target="_blank">Bioon.
com)
Including 8-epicenic acid, geniposide, etc.
) ingredients can coordinately regulate the hypothalamus-pituitary-adrenal (HPA) axis, inflammation, neurotransmitter levels and other links to work together.
At the same time, the study further clarified the key role of intestinal flora in the onset of TG: On the one hand, TG can alleviate HPA axis activation and inflammation levels by regulating Erysipelotrichacea, Peptococcaceae, and a series of bacteria in the Muribculaceae family.
, And inhibit the metabolism of tryptophan-kynurenine to exert an antidepressant effect; on the other hand, hydroxytyrosol (HT), the product of TG metabolized by the intestinal flora, has also been confirmed to be one of its active substances in the body.
In addition, this study also found that TG can relieve hypothalamic-pituitary-gonad axis hypothalamus and cyclic nucleotide abnormalities in depression-like rats, which reflects the scientific connotation and advantages consistent with the traditional efficacy of Cistanche for nourishing the kidney and yang.
As a result, it explained the material basis and mechanism of Cistanche's antidepressant effect from multiple angles, provided strong support for the application and development of Cistanche in the treatment of bioon.
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">depression, and interpreted traditional Chinese medicine theories with modern medical methods.
(bioon.
com" target="_blank">Bioon.
com)
Recently, the internationally renowned journal Phytomedicine published online the latest research results of Professor Li Xiaobo's group from Shanghai Jiaotong University School of Pharmacy entitled "Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota".
The study explained in detail the antidepressant medicinal substances and mechanism of Cistanche, and provided new ideas for the interpretation of the traditional efficacy of Cistanche and the in-depth study of the biological activity of Cistanche.
The study explained in detail the antidepressant medicinal substances and mechanism of Cistanche, and provided new ideas for the interpretation of the traditional efficacy of Cistanche and the in-depth study of the biological activity of Cistanche.
Cistanches Herba (Cistanches Herba) is a traditional Chinese medicine that has been used frequently to invigorate the kidney and yang.
It is the dry fleshy stem with phosphorus leaves of Cistanche deserticola YCMa and/or C.
tubulosa (Schenk) Wight.
Cistanche is a parasitic plant, and its hosts are desert, desert sand-fixing plants Haloxylon, Tamarix, etc.
China is one of the countries with a large area of desertified land and the most serious harm in the world.
Preventing desertification is an important issue that needs to be solved urgently in our country.
By planting Cistanche, driving the planting of sand-fixing plants such as Haloxylon ammodendron and Tamarisk, it can prevent sand and fix sand, play a role in desert control and improve the environment in the west, and it can also drive local ethnic minority people out of poverty and become rich.
It has advantages in comprehensive utilization and industrial development.
Strong social benefits.
Therefore, under the guidance of the traditional effects of Cistanche, the in-depth exploration of the new effects and uses of Cistanche has important guiding significance for the large-scale cultivation of Cistanche and the development of its industry.
The traditional Chinese medicine theory believes that it is the root of yang and the source of power; insufficient kidney yang can lead to abnormal consciousness, stagnation of qi, and symptoms of depression, loss of interest, sentimentality, etc.
; this is consistent with modern medicine.
The symptoms of bioon.
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">depression are similar, suggesting that traditional kidney-yang drugs may have potential antidepressant activity.
The research group of Professor Li Xiaobo, School of Pharmacy, Shanghai Jiaotong University, has been engaged in traditional Chinese medicine and modernization of Chinese medicine for a long time.
The previous 6 years of research confirmed that the kidney-yang Chinese medicine Cistanche has significant antidepressant activity, but its specific active substances and mechanism of action are still unclear.
bioon. It is the dry fleshy stem with phosphorus leaves of Cistanche deserticola YCMa and/or C.
tubulosa (Schenk) Wight.
Cistanche is a parasitic plant, and its hosts are desert, desert sand-fixing plants Haloxylon, Tamarix, etc.
China is one of the countries with a large area of desertified land and the most serious harm in the world.
Preventing desertification is an important issue that needs to be solved urgently in our country.
By planting Cistanche, driving the planting of sand-fixing plants such as Haloxylon ammodendron and Tamarisk, it can prevent sand and fix sand, play a role in desert control and improve the environment in the west, and it can also drive local ethnic minority people out of poverty and become rich.
It has advantages in comprehensive utilization and industrial development.
Strong social benefits.
Therefore, under the guidance of the traditional effects of Cistanche, the in-depth exploration of the new effects and uses of Cistanche has important guiding significance for the large-scale cultivation of Cistanche and the development of its industry.
The traditional Chinese medicine theory believes that it is the root of yang and the source of power; insufficient kidney yang can lead to abnormal consciousness, stagnation of qi, and symptoms of depression, loss of interest, sentimentality, etc.
; this is consistent with modern medicine.
The symptoms of bioon.
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">depression are similar, suggesting that traditional kidney-yang drugs may have potential antidepressant activity.
The research group of Professor Li Xiaobo, School of Pharmacy, Shanghai Jiaotong University, has been engaged in traditional Chinese medicine and modernization of Chinese medicine for a long time.
The previous 6 years of research confirmed that the kidney-yang Chinese medicine Cistanche has significant antidepressant activity, but its specific active substances and mechanism of action are still unclear.
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">Depression
This study is the first time that the total glycosides of Cistanche cistanche (TG) is the basis of its antidepressant medicinal effect.
Including 8-epicenic acid, geniposide, etc.
) ingredients can coordinately regulate the hypothalamus-pituitary-adrenal (HPA) axis, inflammation, neurotransmitter levels and other links to work together.
At the same time, the study further clarified the key role of intestinal flora in the onset of TG: On the one hand, TG can alleviate HPA axis activation and inflammation levels by regulating Erysipelotrichacea, Peptococcaceae, and a series of bacteria in the Muribculaceae family.
, And inhibit the metabolism of tryptophan-kynurenine to exert an antidepressant effect; on the other hand, hydroxytyrosol (HT), the product of TG metabolized by the intestinal flora, has also been confirmed to be one of its active substances in the body.
In addition, this study also found that TG can relieve hypothalamic-pituitary-gonad axis hypothalamus and cyclic nucleotide abnormalities in depression-like rats, which reflects the scientific connotation and advantages consistent with the traditional efficacy of Cistanche for nourishing the kidney and yang.
As a result, it explained the material basis and mechanism of Cistanche's antidepressant effect from multiple angles, provided strong support for the application and development of Cistanche in the treatment of bioon.
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">depression, and interpreted traditional Chinese medicine theories with modern medical methods.
(bioon.
com" target="_blank">Bioon.
com)
bioon. Including 8-epicenic acid, geniposide, etc.
) ingredients can coordinately regulate the hypothalamus-pituitary-adrenal (HPA) axis, inflammation, neurotransmitter levels and other links to work together.
At the same time, the study further clarified the key role of intestinal flora in the onset of TG: On the one hand, TG can alleviate HPA axis activation and inflammation levels by regulating Erysipelotrichacea, Peptococcaceae, and a series of bacteria in the Muribculaceae family.
, And inhibit the metabolism of tryptophan-kynurenine to exert an antidepressant effect; on the other hand, hydroxytyrosol (HT), the product of TG metabolized by the intestinal flora, has also been confirmed to be one of its active substances in the body.
In addition, this study also found that TG can relieve hypothalamic-pituitary-gonad axis hypothalamus and cyclic nucleotide abnormalities in depression-like rats, which reflects the scientific connotation and advantages consistent with the traditional efficacy of Cistanche for nourishing the kidney and yang.
As a result, it explained the material basis and mechanism of Cistanche's antidepressant effect from multiple angles, provided strong support for the application and development of Cistanche in the treatment of bioon.
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">depression, and interpreted traditional Chinese medicine theories with modern medical methods.
(bioon.
com" target="_blank">Bioon.
com)
com/tags/%E6%8A%91%E9%83%81%E7%97%87/" target="_blank">Depressionbioon.
com" target="_blank">
