Research progress of lung cancer stem cells based on specific binding peptides in Suzhou Institute of nanotechnology, Chinese Academy of Sciences

Cancer stem cells have the potential of self-renewal, unlimited proliferation and multi-directional differentiation, which is the source of tumor initiation, growth, recurrence, metastasis and drug resistance The study of tumor stem cells has revolutionary significance in the early diagnosis, effective treatment and prognosis monitoring of tumors With the support of NSFC and Chinese Academy of Sciences, Zhu Yimin, researcher of Suzhou Institute of nanotechnology and nano bionics, Chinese Academy of Sciences, established a detection and separation method of lung cancer stem cells independent of molecular markers based on the screening of specific binding peptides of lung cancer stem cells, which laid an experimental foundation for the research of tumor stem cells At the same time, through the analysis of the microRNA expression profile of polypeptide binding tumor stem cells, it is found that there are different subpopulations of tumor stem cells, polypeptides can be used for the study of tumor stem cell subpopulations, and miRNA can be used as biomarkers of tumor stem cells or even different subpopulations The related work was published in cancer lett, 351 (2014) 100-107 Because the targeted treatment for different subsets of tumor stem cells can make tumor treatment more effective and conform to the current trend of personalized medical treatment, researchers investigated the possible causes of tumor stem cell heterogeneity, studied the common tools for heterogeneity, and currently adopted treatment strategies for heterogeneity, and comprehensively discussed them, hoping to be able to provide cancer stem The study of cell heterogeneity provides theoretical and experimental basis, and the related literature is published in cancer lett, 2015, 357 (1), 63-68 This series of work was supported by the National Natural Science Foundation of China (No 81171451, 81372361 and 30870683) and the Chinese Academy of Sciences (according to: Chinese Academy of Sciences)