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TextSmall Silt
Diabetes is one of the serious global health problems.
1.
1.
The pH-triggered insulin release system utilizes the gluconic acid produced when GOx oxidizes glucose, causing local pH to decrease, which in turn triggers changes in the carrier structure (dissociation, swelling, or collapse), and ultimately leads to drug release
H2O2 triggers the insulin release system to use the H2O2 generated when GOx oxidizes glucose to trigger the release of insulin
2.
2.
Although the Con A insulin delivery system has made some progress, the system still has some limitations, including its toxicity, water solubility, stability and long response time
3.
3.
The PBA insulin delivery system based on the swelling mechanism usually loads insulin on the hydrogel network or wraps it inside the hydrogel.
In addition, in order to enhance the glucose sensitivity of the PBA system, some studies have combined the use of GOx and PBA
A safe and effective insulin delivery system is expected to enhance the effect of drug treatment and improve the quality of life of patients
references
[1] Liu Hui, Li Qinwen, Xu Shuang, Ma Yujing, He Jun, Cai Xin, Yi Fang.
[2] Xu Jiafu.
