Research progress of bacterial membrane nano-tumor vaccine

Recently, the research team of Zhao Xiao, Zhao Ruifang and Nie Guangjun of the National Nanoscience Center of the Chinese Academy of Sciences has made important progress in bacterial membrane nano-tumor vaccine

There are a large number of gene mutations in tumor cells, some of which produce mutant polypeptides that have the potential to activate immune responses, called tumor antigens

Based on the concept of carrier-adjuvant integration, and inspired by the natural phenomenon that the body recognizes bacteria and generates immunity, the scientific research team has long been committed to the development and research of nano-tumor vaccines based on bacterial membrane materials

On the basis of the previous work, the researchers analyzed the technical details of these two bacterial membrane nano-tumor vaccines with different technical routes, and summarized their vaccine characterization, immune effect evaluation and anti-tumor effect evaluation methods in various tumor models

The research work is supported by the National Key R&D Program, the Chinese Academy of Sciences' Strategic Pilot Science and Technology Project, the Chinese Academy of Sciences Basic Research Youth Team Project, the Beijing Science and Technology Rising Star Program, the National Natural Science Foundation of China, and the Guangdong Provincial Key Field R&D Program

Schematic diagram of the technical route for the preparation of two nano-tumor vaccines based on bacterial membrane materials 

Source: National Nanoscience Center, Chinese Academy of Sciences