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(Correspondent Wang Qiang) On February 18, 2022, Professor Li Zifu and Professor Yang Xiangliang from the School of Life Science and Technology and the National Nanomedicine Engineering Technology Research Center published an article entitled "Influence of Linkers within Stimuli" in the internationally renowned journal Chemistry of Materials.
In the research and development of new drugs, the prodrug strategy has become a classic drug design method
The linker is an important component of the above-mentioned prodrug conjugated drug, which determines the release rate and amount of the drug at the lesion site
Based on the above background, in this study, five different linker-conjugated doxorubicin (DOX) dimers were designed and synthesized: DOX2-CC linked with stable fatty chain, DOX2-SS (SH ), GSH-responsive and DOX2-SS with original drug release, H2O2-responsive and original drug-released DOX2-Bor, and acid-responsive and original drug-released DOX2-DMA, and were observed in mouse triple-negative breast cancer in situ tumors and Two different tumor-bearing mouse models of hepatocellular carcinoma were compared for their antitumor efficacy
Based on the above results, this study proposes a "precise and traceless" linker design strategy
Doctoral students Wang Qiang, Wang Chong and Li Shiyou from the School of Life Sciences of Huazhong University of Science and Technology are the co-first authors of the paper
Article link: https://pubs.
