Research group of Professor Shen qundong of Nanjing University regulates microenvironment homeostasis of tumor cells by nano drug delivery system for combined treatment of tumor

Molecular biology studies have found that reactive oxygen stress caused by ROS and endoplasmic reticulum stress caused by misfolded proteins are common in tumor cells, which are important reasons for the insensitivity of tumor cells to chemotherapy or photodynamic therapy Destroying the homeostasis of tumor cells in the process of tumor treatment can not only increase the sensitivity of tumor cells to traditional chemotherapy drugs, but also improve the effect of photodynamic therapy Shen qundong, Professor of the Department of polymer science and engineering, School of chemistry and chemical engineering, Nanjing University, and the research group of the collaborative innovation center of life chemistry, proposed a nano drug delivery system (rddg / DC) for combined treatment of small tumors (DOI: 10.1002/small.201900212), which combines photodynamic therapy and regulation of tumor cell stress microenvironment homeostasis The system is composed of 2-deoxyglucose (2-DG) and ROS sensitive polymer, which is linked to the endoplasmic reticulum stress of tumor cells At the same time, it contains chemotherapy drugs (DOX) and photodynamic therapy photosensitizers In light, photosensitizers can be used as photodynamic therapy and also emit near-infrared fluorescence for high-resolution imaging in vivo The active oxygen produced by photodynamic therapy can induce the release of 2-DG from the nano drug loading system and induce endoplasmic reticulum stress of tumor cells, while the rise of endoplasmic reticulum stress can further improve the oxidative stress killing effect of photodynamic therapy and the cytotoxic effect of DOX, so as to effectively promote the apoptosis of tumor cells The results showed that the nano drug loading system significantly increased the level of endoplasmic reticulum stress, enhanced the level of reactive oxygen species produced by photodynamic therapy, promoted the outflow of cytochrome C in mitochondria, and induced apoptosis of tumor cells In addition, the effect of the nano drug loading system on tumor growth inhibition in vivo was further verified In recent years, Professor Shen qundong's research group has focused on the research of functional polymer integrated diagnosis and treatment system The first author of the thesis is Dong Mei, a doctoral student The research project is supported by key projects of national key R & D plan, National Natural Science Foundation, Yangtze River scholars and innovation team development plan, etc.