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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Liz Zee Guide: A research team led by University College London (UCL) has discovered an antiviral gene that affects both Alzheimer's disease and severe Covid-19
.
Researchers estimate that genetic variants in the OAS1 gene increase the overall risk of Alzheimer's disease by about 3-6%, while related variants in the OAS1 gene increase the likelihood of severe Covid-19
.
The discovery was published yesterday (October 7) in "Brain" with the paper titled "A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene"
.
This discovery may open the door for the development of new targets or tracking disease progression for these two diseases, and shows that the developed treatments can be used for these two diseases
.
In addition, this discovery has potential benefits for other related infectious diseases and dementia
.
Lead author Dr.
Dervis Salih said: “Although the main feature of Alzheimer’s disease is the accumulation and tangles of harmful amyloid in the brain, there is also extensive inflammation in the brain, which highlights the immune system’s role in Alzheimer’s disease.
the importance of
.
we found that Alzheimer's disease and Covid-19 may be some of the same immune system will change
.
"" Covid-19 serious brain infection in patients with inflammatory changes may also occur
.
We have discovered a gene that causes an excessive immune response, which increases the risk of Alzheimer’s disease and Covid-19
.
"In this study, the research team tried to build on their previous work.
They found evidence from a large amount of human genome data that there is a link between the OAS1 gene and Alzheimer's disease
.
The
OAS1 gene is in Xiaojiao .
Microglia is a type of immune cell, which accounts for about 10% of all cells in the brain
.
In order to further study the link between this gene and Alzheimer’s disease, they sequenced the genetic data of 2,547 people.
Half of them have Alzheimer's disease
.
They found that people with a special mutation in the OAS1 gene (named rs1131454) are more likely to have Alzheimer's disease, and their carriers have a baseline risk of Alzheimer's disease An increase of about 11-22%
.
This newly discovered variant is very common, it is believed that more than half of Europeans carry this variant, and it has a greater impact on the risk of Alzheimer’s disease than several other known risks The gene is larger
.
Their discovery adds an antiviral gene OAS1 to dozens of genes currently known to affect the risk of Alzheimer’s disease
.
The
researchers investigated four variants of the OAS1 gene, all of which are Suppresses its expression (activity)
.
They found that variants that increase the risk of Alzheimer’s disease are related to the recently discovered OAS1 variants, which increase the baseline risk of severe Covid-19 by 20%
.
As part of the study, The researchers found in the simulation of immune cells affected by Covid-19 that the gene controls the amount of pro-inflammatory proteins released by human immune cells
.
They found that microglia with weaker gene expression overreacted to tissue damage, releasing what they called a "cytokine storm", causing the body to attack its own autoimmune state
.
OAS1’s activities change with age, so further research on gene networks may help understand why older people are more likely to develop Alzheimer’s disease, Covid-19, and other related diseases
.
Dr.
Naciye Magusali said: “Our findings indicate that regardless of age, some people may be more susceptible to Alzheimer’s disease and severe Covid-19 because some of our immune cells seem to share common molecules in these two diseases.
Mechanism
.
" After the outbreak of the Covid-19 pandemic, researchers from the UK Dementia Institute at University College London turned their attention to studying the long-term nervous system effects of the virus
.
They used biomarkers found in the blood and fluid around the central nervous system to track neuroinflammation and damage to neurons
.
Dr.
Salih said: “If we can develop a simple method to detect these genetic variants when people test positive for Covid-19, then it will be possible to determine who is more likely to develop severe illness, but let us reach this level.
There is still a lot of work to be done
.
Similarly, we hope that our research can promote the development of blood tests to determine whether people are at risk of Alzheimer’s disease before memory problems occur
.
” “We are still continuing to study, once What happens when this immune network is activated in response to infections like Covid-19, to see if it causes any lasting effects or weakness, or if the brain’s immune response to Covid-19 is understood, including the OAS1 gene, this May help explain some of the neurological effects of Covid-19
.
"Reference: https://academic.
oup.
com/brain/advance-article/doi/10.
1093/brain/awab337/6382473?searchresult=1 Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
For
example, If you need health guidance, please go to a regular hospital for treatment
.
The
popular article Diagnostic Test [The Lancet] calls for action! Nearly half of the world's people cannot get basic diagnosis for many common diseases.
Can the COVID-19 pandemic help change the diagnosis status? Immunotherapy [Nature Sub-Journal] Lung epithelial cells control lung immunity? This will lay the foundation for the treatment of a variety of lung diseases! Tumor research [Research] Be vigilant! Sum up 30 years of big data: esophageal adenocarcinoma is showing a younger trend Medicine News [News] The Nobel Prize in Physiology or Medicine in 2021 will be announced, and pain receptors will be awarded! Intestinal health [PNAS] research has found that the "second brain" exists in the intestine, and its glial will open up new ways for the treatment of intestinal diseases Approach! Cancer Research [Nature Sub-Journal] Using single-cell multiomics to study tumor cells with new ideas, top-level teams such as Harvard Medical School create a precedent! Cancer research [Science] protein may become a new breakthrough in cancer treatment! New coronavirus [ Science] The truth about the source of SARS-CoV-2 is revealed? The coronavirus that is closest to the new coronavirus has been found in Lao bats so far, with a matching rate of 96.
8%! The new crown virus [The BMJ] has an inoculation rate of 78% in Israel, why the epidemic is still Out of control? Is there any need to worry about the effectiveness of the new crown vaccine? Is it necessary to strengthen the needle? Organoid research [Nature] The 3D pancreatic cancer tumor model cultivated by an international team of scientists including Shanghai Jiaotong University can effectively improve the treatment of pancreatic cancer Methods Tumor Research [Science Sub-Journal] Table salt has the effect of inhibiting tumors? Scientists explain unexpected discoveries through mouse experiments! Recommendations·Activities The 3rd Shanghai International Cancer Conference The 5th Modern Clinical Molecular Diagnosis Symposium
Please indicate the source for reprinting.
Author: Liz Zee Guide: A research team led by University College London (UCL) has discovered an antiviral gene that affects both Alzheimer's disease and severe Covid-19
.
Researchers estimate that genetic variants in the OAS1 gene increase the overall risk of Alzheimer's disease by about 3-6%, while related variants in the OAS1 gene increase the likelihood of severe Covid-19
.
The discovery was published yesterday (October 7) in "Brain" with the paper titled "A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene"
.
This discovery may open the door for the development of new targets or tracking disease progression for these two diseases, and shows that the developed treatments can be used for these two diseases
.
In addition, this discovery has potential benefits for other related infectious diseases and dementia
.
Lead author Dr.
Dervis Salih said: “Although the main feature of Alzheimer’s disease is the accumulation and tangles of harmful amyloid in the brain, there is also extensive inflammation in the brain, which highlights the immune system’s role in Alzheimer’s disease.
the importance of
.
we found that Alzheimer's disease and Covid-19 may be some of the same immune system will change
.
"" Covid-19 serious brain infection in patients with inflammatory changes may also occur
.
We have discovered a gene that causes an excessive immune response, which increases the risk of Alzheimer’s disease and Covid-19
.
"In this study, the research team tried to build on their previous work.
They found evidence from a large amount of human genome data that there is a link between the OAS1 gene and Alzheimer's disease
.
The
OAS1 gene is in Xiaojiao .
Microglia is a type of immune cell, which accounts for about 10% of all cells in the brain
.
In order to further study the link between this gene and Alzheimer’s disease, they sequenced the genetic data of 2,547 people.
Half of them have Alzheimer's disease
.
They found that people with a special mutation in the OAS1 gene (named rs1131454) are more likely to have Alzheimer's disease, and their carriers have a baseline risk of Alzheimer's disease An increase of about 11-22%
.
This newly discovered variant is very common, it is believed that more than half of Europeans carry this variant, and it has a greater impact on the risk of Alzheimer’s disease than several other known risks The gene is larger
.
Their discovery adds an antiviral gene OAS1 to dozens of genes currently known to affect the risk of Alzheimer’s disease
.
The
researchers investigated four variants of the OAS1 gene, all of which are Suppresses its expression (activity)
.
They found that variants that increase the risk of Alzheimer’s disease are related to the recently discovered OAS1 variants, which increase the baseline risk of severe Covid-19 by 20%
.
As part of the study, The researchers found in the simulation of immune cells affected by Covid-19 that the gene controls the amount of pro-inflammatory proteins released by human immune cells
.
They found that microglia with weaker gene expression overreacted to tissue damage, releasing what they called a "cytokine storm", causing the body to attack its own autoimmune state
.
OAS1’s activities change with age, so further research on gene networks may help understand why older people are more likely to develop Alzheimer’s disease, Covid-19, and other related diseases
.
Dr.
Naciye Magusali said: “Our findings indicate that regardless of age, some people may be more susceptible to Alzheimer’s disease and severe Covid-19 because some of our immune cells seem to share common molecules in these two diseases.
Mechanism
.
" After the outbreak of the Covid-19 pandemic, researchers from the UK Dementia Institute at University College London turned their attention to studying the long-term nervous system effects of the virus
.
They used biomarkers found in the blood and fluid around the central nervous system to track neuroinflammation and damage to neurons
.
Dr.
Salih said: “If we can develop a simple method to detect these genetic variants when people test positive for Covid-19, then it will be possible to determine who is more likely to develop severe illness, but let us reach this level.
There is still a lot of work to be done
.
Similarly, we hope that our research can promote the development of blood tests to determine whether people are at risk of Alzheimer’s disease before memory problems occur
.
” “We are still continuing to study, once What happens when this immune network is activated in response to infections like Covid-19, to see if it causes any lasting effects or weakness, or if the brain’s immune response to Covid-19 is understood, including the OAS1 gene, this May help explain some of the neurological effects of Covid-19
.
"Reference: https://academic.
oup.
com/brain/advance-article/doi/10.
1093/brain/awab337/6382473?searchresult=1 Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
For
example, If you need health guidance, please go to a regular hospital for treatment
.
The
popular article Diagnostic Test [The Lancet] calls for action! Nearly half of the world's people cannot get basic diagnosis for many common diseases.
Can the COVID-19 pandemic help change the diagnosis status? Immunotherapy [Nature Sub-Journal] Lung epithelial cells control lung immunity? This will lay the foundation for the treatment of a variety of lung diseases! Tumor research [Research] Be vigilant! Sum up 30 years of big data: esophageal adenocarcinoma is showing a younger trend Medicine News [News] The Nobel Prize in Physiology or Medicine in 2021 will be announced, and pain receptors will be awarded! Intestinal health [PNAS] research has found that the "second brain" exists in the intestine, and its glial will open up new ways for the treatment of intestinal diseases Approach! Cancer Research [Nature Sub-Journal] Using single-cell multiomics to study tumor cells with new ideas, top-level teams such as Harvard Medical School create a precedent! Cancer research [Science] protein may become a new breakthrough in cancer treatment! New coronavirus [ Science] The truth about the source of SARS-CoV-2 is revealed? The coronavirus that is closest to the new coronavirus has been found in Lao bats so far, with a matching rate of 96.
8%! The new crown virus [The BMJ] has an inoculation rate of 78% in Israel, why the epidemic is still Out of control? Is there any need to worry about the effectiveness of the new crown vaccine? Is it necessary to strengthen the needle? Organoid research [Nature] The 3D pancreatic cancer tumor model cultivated by an international team of scientists including Shanghai Jiaotong University can effectively improve the treatment of pancreatic cancer Methods Tumor Research [Science Sub-Journal] Table salt has the effect of inhibiting tumors? Scientists explain unexpected discoveries through mouse experiments! Recommendations·Activities The 3rd Shanghai International Cancer Conference The 5th Modern Clinical Molecular Diagnosis Symposium
