Research by the University of Southampton has found that the ADAMTSL1 gene variant shortens the life cycle of breast cancer patients.

Women under the age of 40 who are diagnosed with early-stage breast cancer tend to have lower relative survival rates than older women diagnosed with breast cancer, but why? A new study has found a potential genetic explanation.
researchers at the University of Southampton in the UK found that women aged 15-39 with early-stage breast cancer had specific genetic variants associated with worsening the condition.
the team says their findings not only reveal why young women with breast cancer have lower survival rates, but also provide new therapeutic targets for the disease.
breast cancer is the most common cancer among American women after skin cancer;
breast cancer is most common among women over the age of 40.
But when young women have a lower risk of breast cancer, their relative survival rate decreases when they are diagnosed with breast cancer. younger women
are often diagnosed with breast cancer because the disease is more harmful, which may partly explain their poor survival rates.
However, new research by Dr Tapper and his colleagues suggests that certain genetic variants may also play a role.
the mutations found in the ADAMTSL1 gene analyzed four groups of people, including a total of 6,042 women who had been diagnosed with breast cancer.
of these women, 2,315 were between the ages of 15 and 39.
team studied the stage of diagnosis of breast cancer, the overall survival of women, and their gene expression.
in young women diagnosed with early-onset breast cancer, two mononucleotide polymorphisms (SNPs) in the ADAMTSL1 gene were found to be associated with a greater risk of disease progression.
SNPs are variations of DNA sequences that can affect the function of genes, which play an important role in disease.
researchers say the findings "suggest that unique disease mechanisms may affect the survival of young women and provide some biological insights into why young breast cancer patients have a worse prognosis."
"," Dr Tapper and his team say, the findings will provide new diagnostic and therapeutic methods for young women diagnosing early-stage breast cancer. "Our findings increase our understanding of the genes and pathways associated with breast cancer prognosis and may provide new targets for the development of new therapies,"
.
" This genetic factor may be used to improve prognosis models in the short to medium term.
", he added, "when more people know about this association and its relationship to treatment responses, it may affect the most effective treatments for breast cancer."
" Source: Decoding Medicine.