"Reprogramming" cells allow large wounds to heal as much as they can

in countries such as the United States have successfully "reprogrammed" cells in wounds and converted them into pregenits of skin cells, helping to heal skin wounds. This technique can also be used to repair skin damage and anti-aging, and can also help to further understand the pathogenesis of skin cancer.
study, published in the British journal
, showed that specific reprogramming factors in mice helped normal skin cells convert into base cells and grow into healthy endocal cells within 18 days.
the base of the cell is a stem cell-like cell, is a prelude to different types of skin cells. But severe wounds often lack such cells. In addition, during wound healing, cells at the wound are primarily involved in wound closure and inflammatory responses, rather than rebuilding healthy skin.
the researchers first identified 55 "reprogramming factors" associated with substrate horn formation cells, and then determined that four of the determining factors could mediate the conversion of other skin cells into substrate kerate formation cells. When treating skin ulcers in mice with these four decisive factors, they found that ulcers grew healthy endothoste cells within 18 days, and that corted cells gradually expanded to allow large areas of ulcers to heal;
of skin ulcers is mainly manifested in the long-term insalication of the wound. At present, the treatment of skin ulcers usually requires the transplant of existing skin, but when the ulcer is too large, it is often difficult to find large enough skin for transplantation, and the extraction of skin stem cells in the laboratory culture is more time-consuming.
, the study's author and a professor at the Salk Institute in the United States, says the new approach is not just the regeneration of a single type of cell, but the regeneration of all three-dimensional tissues like the skin. This method may also provide guidance for other in vivo regeneration therapies in the future. (Source: Xinhua News Agency Zhou Zhou)