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Reduce cough frequency by 34%, innovative P2X3 receptor antagonist Phase 2 clinical results are positive

 Last Update: 2021-12-29
 Source: Internet
 Author: User

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On December 13, 2021, Bellus Health announced that a phase 2b clinical trial of the selective oral P2X3 receptor antagonist BLU-5937 has obtained positive results

P2X3 receptors are ion channels expressed on sensory nerves, and they play an important role in the sensitization of various stimuli in the nervous system

The results of the test showed that on the 28th day, the placebo-adjusted 24-hour cough frequency of the 50 mg and 200 mg BLU-5937 groups was reduced by 34%, which was clinically significant and statistically significant (p≤0.

▲Efficacy results of BLU-5937 (picture source: BELLUS Health official website)

In addition, the safety and tolerability data of BLU-5937 are consistent with previous trials, and have a lower impact on patients' taste.

Reference materials:

[1] BELLUS Health Announces Positive Topline Results from its Phase 2b SOOTHE Trial of BLU-5937 for the Treatment of Refractory Chronic Cough.

(The original text has been deleted)

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